Evidence map›Paper›PMID 30649347›Full record

ArticleThe Journal of clinical endocrinology and metabolism2019

Adipose Insulin Resistance in Normal-Weight Women With Polycystic Ovary Syndrome.

Daniel A Dumesic, Julia D Phan, Karen L Leung, Tristan R Grogan, Xiangmiang Ding, Xinmin Li, Luis R Hoyos, David H Abbott, Gregorio D Chazenbalk

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 3 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Adipose Tissue Dysfunction in Polycystic Ovary Syndrome.The Journal of clinical endocrinology and metabolism · 2023
    Pooled it
  4. Trial
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Targeted metabolomics and fatty acid profiling in lean and obese polycystic ovarian syndrome patients: A pilot study.European journal of obstetrics & gynecology and reproductive biology: X · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. On the Intimate Relationship of Adiposity to Polycystic Ovary Syndrome.The Journal of clinical endocrinology and metabolism · 2025
    Review
  15. Review
  16. Polycystic ovary syndrome as a metabolic disease.Nature reviews. Endocrinology · 2025
    Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Daniel A DumesicDepartment of Obstetrics and Gynecology, David Geffen School of Medicine at University of California, Los Angeles, California.
Julia D PhanDepartment of Obstetrics and Gynecology, David Geffen School of Medicine at University of California, Los Angeles, California.
Karen L LeungDepartment of Obstetrics and Gynecology, David Geffen School of Medicine at University of California, Los Angeles, California.
Tristan R GroganDepartment of Medicine Statistics Core, David Geffen School of Medicine at University of California, Los Angeles, California.
Xiangmiang DingTechnology Center for Genomics and Bioinformatics, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California.
Xinmin LiTechnology Center for Genomics and Bioinformatics, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California.
Luis R HoyosDepartment of Obstetrics and Gynecology, David Geffen School of Medicine at University of California, Los Angeles, California.
David H AbbottDepartment of Obstetrics and Gynecology and Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin.
Gregorio D ChazenbalkDepartment of Obstetrics and Gynecology, David Geffen School of Medicine at University of California, Los Angeles, California.
University of California, Los Angeles · USUniversity of Wisconsin–Madison · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
PROJECT 4: ANDROGEN EXCESS IN ADIPOGENIC DYSFUNCTION IN PCOS WOMENP50HD071836 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI STOUFFER, RICHARD L · 2014 to 2021
$14.7M
NCATS NIH HHS UL1 TR001881NICHD NIH HHS P50 HD071836NIH HHS P51 OD011092
6 · The paper itself

Abstract

contextNormal-weight women with polycystic ovary syndrome (PCOS) may have adipose tissue insulin resistance (adipose-IR).

objectiveTo examine whether adipose-IR and subcutaneous (SC) abdominal adipose stem cell (ASC) gene expression are altered in normal-weight women with PCOS and correlated with hyperandrogenemia and/or whole-body IR.

designProspective cohort study.

settingAcademic medical center. PATIENTS: Ten normal-weight women with PCOS and 18 control subjects matched for age and body mass index. INTERVENTION(S): Women underwent circulating hormone and metabolic measurements, IV glucose tolerance testing, total-body dual-energy x-ray absorptiometry, and SC abdominal fat biopsy. MAIN OUTCOME MEASURE(S): Adipose-IR (fasting insulin × total fatty acid levels) and SC abdominal ASC gene expression were compared between groups and correlated with clinical outcomes.

resultsAdipose-IR was greater in women with PCOS than in control subjects (P < 0.01), with 29 pmol/L × mmol/L providing 94% specificity and 80% sensitivity in discriminating the two groups (P < 0.001). Adipose-IR positively correlated with serum androgen and log of fasting triglyceride (TG) levels, percentage of small adipocytes (P < 0.01, all correlations), and acute insulin response to glucose (P < 0.05); and negatively correlated with insulin sensitivity (Si; P < 0.025) and serum adiponectin levels (P < 0.05). Adjusting for serum androgens, adipose-IR correlations with Si and log TG levels remained significant. ASC genes were differentially expressed by the two groups. Expression of functionally critical genes was associated with serum testosterone and/or fasting insulin levels.

conclusionNormal-weight women with PCOS have increased adipose-IR and altered ASC gene expression related to hyperandrogenism and IR.

Indexed as

Insulin ResistanceAdiponectinAdultFemaleGene Expression RegulationHumansPolycystic Ovary SyndromeSubcutaneous Fat, AbdominalTestosteroneTransforming Growth Factor betaTriglyceridesAdiponectinADIPOQ protein, humanTestosteroneTransforming Growth Factor betaTriglycerides

Identifiers

PMID30649347
PMCPMC6482023
OpenAlexW2944329517

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.