Evidence map›Paper›PMID 30649160›Full record

ArticleAlcohol and alcoholism (Oxford, Oxfordshire)2019

Does Self-Reported or Behavioral Impulsivity Predict Subjective Response to Low-Dose Alcohol?

Benjamin L Berey, Robert F Leeman, Brian Pittman, Nicholas Franco, Suchitra Krishnan-Sarin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcohol and alcoholism (Oxford, Oxfordshire), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
  3. Moderators of subjective response to alcohol in the human laboratory.Alcoholism, clinical and experimental research · 2022
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Benjamin L BereyDepartment of Health Education and Behavior, University of Florida, 1908 Stadium Road, Gainesville, FL, USA.
Robert F LeemanDepartment of Health Education and Behavior, University of Florida, 1908 Stadium Road, Gainesville, FL, USA.
Brian PittmanDepartment of Psychiatry, School of Medicine, Yale University, 34 Park Street, New Haven, CT, USA.
Nicholas FrancoDepartment of Psychiatry, School of Medicine, Yale University, 34 Park Street, New Haven, CT, USA.
Suchitra Krishnan-SarinDepartment of Psychiatry, School of Medicine, Yale University, 34 Park Street, New Haven, CT, USA.
Yale University · USUniversity of Florida · US

Funding

Translational Technologies CoreP50AA012870 · NIAAA · YALE UNIVERSITY · PI John H. Krystal · 2001 to 2026
$43.7M
ZIPRASIDONE IN TOURETTES SYNDROME, OBSESSIVE COMPULSIVE &PERVASIVE DEV. DISORDERM01RR000125 · NCRR · YALE UNIVERSITY · PI ALPERN, ROBERT J · 1985 to 2006
$24.1M
Translational Science Training to Reduce the Impact of Alcohol on HIV InfectionT32AA025877 · NIAAA · UNIVERSITY OF FLORIDA · PI Robert L Cook, DEBRA E LYON · 2018 to 2026
$3.3M
Testing a Smartphone Breathalyzer and BAC Estimator in Young Adult Heavy DrinkersR21AA023368 · NIAAA · UNIVERSITY OF FLORIDA · PI LEEMAN, ROBERT F · 2016 to 2017
$384k
NCRR NIH HHS M01 RR000125NIAAA NIH HHS P50 AA012870NIAAA NIH HHS R21 AA023368NIAAA NIH HHS T32 AA025877
6 · The paper itself

Abstract

aimsSubjective response to alcohol and impulsivity are both independent predictors of alcohol use and may be related risk factors for alcohol use disorders (AUDs). Recent findings suggest that more impulsive individuals may experience higher risk subjective response patterns at moderate-to-high doses of alcohol. However, whether these relationships are observable early in a drinking occasion remains an open question. This study examined multiple measures of impulsivity in relation to subjective response following low-dose alcohol.

methodEighty-seven non-treatment-seeking heavy drinkers were enrolled in a placebo-controlled alcohol administration study testing the effects of NMDA receptor antagonist, Memantine. Baseline impulsivity assessments included the Cued Go/No-Go Task, Experiential Discounting Task, and Barratt Impulsiveness Scale, Version 11 (BIS-11). Following consumption of low-dose alcohol aimed to increase blood alcohol concentration (BAC) to 0.03%, subjective stimulation and sedation were measured using the Biphasic Alcohol Effects Scale. Models were tested to relate impulsivity measures to subjective response with a post hoc exploratory model exploring boredom as an alternate predictor.

resultsIncreases in stimulation and sedation were observed following low-dose alcohol, but were not predicted significantly by impulsivity measures. Although greater impulsivity on the BIS-11 was a trend-level predictor of increased sedation, post hoc analyses suggested these results were an artifact of boredom.

conclusionAlthough impulsivity did not predict subjective response to low-dose alcohol, the results suggest that small amounts of alcohol can produce a range of subjective effects, even among heavy drinkers. Future studies would benefit by examining subjective response across a range of BACs among both light and heavy drinkers.

Indexed as

Impulsive BehaviorSelf ReportAdultAlcohol DrinkingAlcoholismCentral Nervous System StimulantsControlled Clinical Trials as TopicEthanolFemaleHumansHypnotics and SedativesMaleMiddle AgedNeuropsychological TestsRisk FactorsSelf AdministrationCentral Nervous System StimulantsEthanolHypnotics and Sedatives

Identifiers

PMID30649160
PMCPMC6476413
OpenAlexW2910896582

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.