ArticleJournal of acquired immune deficiency syndromes (1999)2019
Chronic Distal Sensory Polyneuropathy Is a Major Contributor to Balance Disturbances in Persons Living With HIV.
Article in Journal of acquired immune deficiency syndromes (1999), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Developing an HIV-specific falls risk prediction model with a novel clinical index: a systematic review and meta-analysis method.BMC infectious diseases · 2024Pooled it
- Higher iron stores and the HFE 187C>G variant delay onset of peripheral neuropathy during combination antiretroviral therapy.PloS one · 2020Trial
- Elevated Biomarkers of Inflammation and Vascular Dysfunction Are Associated with Distal Sensory Polyneuropathy in People with HIV.International journal of molecular sciences · 2024Article
- Higher Levels of Cerebrospinal Fluid and Plasma Neurofilament Light in Human Immunodeficiency Virus-Associated Distal Sensory Polyneuropathy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Neuropathic pain correlates with worsening cognition in people with human immunodeficiency virus.Brain : a journal of neurology · 2022Observational
- Neuropathy in Human Immunodeficiency Virus: A Review of the Underlying Pathogenesis and Treatment.Cureus · 2022Review
- Reduced Gut Microbiome Diversity in People With HIV Who Have Distal Neuropathic Pain.The journal of pain · 2022Article
- Paresthesia Predicts Increased Risk of Distal Neuropathic Pain in Older People with HIV-Associated Sensory Polyneuropathy.Pain medicine (Malden, Mass.) · 2021Article
- Cannabis use is not associated with increased balance disturbances in HIV-infected individuals.Journal of cannabis research · 2021Article
- Falls in people living with HIV: a scoping review.BMJ open · 2020Article
- Predictors of worsening neuropathy and neuropathic pain after 12 years in people with HIV.Annals of clinical and translational neurology · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMedical comorbidities accumulate in older persons living with HIV (PLWH), causing disability and reduced quality of life. Sensory neuropathy and polypharmacy may contribute to balance difficulties and falls. The contribution of neuropathy is understudied.
objectiveTo evaluate the contribution of chronic distal sensory polyneuropathy (cDSPN) to balance disturbances among PLWH.
methodsAmbulatory PLWH and HIV- adults (N = 3379) were prospectively studied. All participants underwent a neurologic examination to document objective abnormality diagnostic of cDSPN and reported neuropathy symptoms including pain, paresthesias, and numbness. Participants provided detailed information regarding balance disturbance and falls over the previous 10 years. Balance disturbances were coded as minimal or none and mild-to-moderate. Covariates included age, HIV disease, and treatment characteristics and medications (sedatives, opioids, and antihypertensives).
resultsEleven percent of participants reported balance disturbances at some time during the last 10 years; the rate in PLWH participants exceeding that for HIV- [odds ratio 2.59, 95% confidence interval: 1.85 to 3.64]. Fifty-two percent met criteria for cDSPN. Balance problems were more common in those with cDSPN [odds ratio = 3.3 (2.6-4.3)]. Adjusting for relevant covariates, balance disturbances attributable to cDSPN were more frequent among HIV+ than HIV- (interaction P = 0.001). Among individuals with cDSPN, older participants were much more likely to report balance disturbances than younger ones.
conclusionscDSPN contributes to balance problems in PLWH. Assessments of cDSPN in older PLWH should be a clinical priority to identify those at risk and to aid in fall prevention and the ensuing consequences, including bone fractures, subdural hematoma, hospital admissions, and fatal injury.
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