Evidence map›Paper›PMID 30648571›Full record

ArticleJournal of food and drug analysis2019

CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-β, Wnt and STAT3 signaling pathways.

In-Yu Lin, Yi-Shiou Chiou, Li-Ching Wu, Chen-Yu Tsai, Chiung-Tong Chen, Wu-Chang Chuang, Ming-Chung Lee, Ching-Che Lin, Ting-Ting Lin, Ssu-Ching Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of food and drug analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Antioxidant therapy against TGF-β/SMAD pathway involved in organ fibrosis.Journal of cellular and molecular medicine · 2024
    Review
  3. Review
  4. Article
  5. Article
  6. Lipophilic Constituents inFrontiers in pharmacology · 2022
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

In-Yu LinDepartment of Biomedical Sciences and Engineering, Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan, Taiwan.
Yi-Shiou ChiouInstitute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.
Li-Ching WuDepartment of Biomedical Sciences and Engineering, Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan, Taiwan.
Chen-Yu TsaiInstitute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.
Chiung-Tong ChenInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli, Taiwan.
Wu-Chang ChuangBrion Research Institute of Taiwan, New Taipei City, Taiwan.
Ming-Chung LeeBrion Research Institute of Taiwan, New Taipei City, Taiwan.
Ching-Che LinBrion Research Institute of Taiwan, New Taipei City, Taiwan.
Ting-Ting LinDepartment of Biomedical Sciences and Engineering, Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan, Taiwan.
Ssu-Ching ChenDepartment of Life Sciences, National Central University, Taoyuan, Taiwan.
Min-Hsiung PanInstitute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.
Nianhan MaDepartment of Biomedical Sciences and Engineering, Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CCM111 is an aqueous extract of Antrodia cinnamomea (AC) that has exhibited anti-liver fibrosis functions. However, the detailed mechanisms of AC action against liver fibrosis have not been elucidated yet. The present research showed that CCM111 significantly lowered the levels of the hepatic enzyme markers glutamate oxaloacetate transaminase (GOT) and glutamic pyruvic transaminase (GPT), prevented liver damage and collagen deposition, and downregulated TGF-β/Smad signaling in a dose-dependent manner compared with CCl

Indexed as

AnimalsAntrodiaDrugs, Chinese HerbalHumansLiverLiver CirrhosisMaleMiceMice, Inbred ICRNF-kappa BSignal TransductionSTAT3 Transcription FactorTransforming Growth Factor betaWnt ProteinsDrugs, Chinese HerbalNF-kappa BStat3 protein, mouseSTAT3 Transcription FactorTransforming Growth Factor betaWnt ProteinsAntrodia cinnamomeaLiver fibrosisSTAT3 pathwayTGF-β pathwayWnt pathway

Identifiers

PMID30648571
PMCPMC9298635

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.