Evidence map›Paper›PMID 30648458›Full record

ArticleTissue engineering. Part C, Methods2019

Using a Three-Dimensional Collagen Matrix to Deliver Respiratory Progenitor Cells to Decellularized Trachea In Vivo.

Nick J I Hamilton, Robert E Hynds, Kate H C Gowers, Angela Tait, Colin R Butler, Colin Hopper, Alan J Burns, Martin A Birchall, Mark Lowdell, Sam M Janes

Abstract read
In one paragraph

Article in Tissue engineering. Part C, Methods, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
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  5. Review
  6. Article
  7. Article
  8. Article
  9. Conditional Cell Reprogramming in Modeling Digestive System Diseases.Frontiers in cell and developmental biology · 2021
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nick J I Hamilton1 Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, University College London, London, United Kingdom.
Robert E Hynds1 Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, University College London, London, United Kingdom.
Kate H C Gowers1 Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, University College London, London, United Kingdom.
Angela Tait3 Department of Biochemical Engineering, University College London, London, United Kingdom.
Colin R Butler1 Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, University College London, London, United Kingdom.
Colin Hopper4 Maxillofacial Surgery, Eastman Dental Institute, London, United Kingdom.
Alan J Burns5 Stem Cell and Regenerative Medicine, Birth Defects Research Centre, UCL Great Ormond Institute of Child Health, London, United Kingdom.
Martin A Birchall2 UCL Ear Institute, The Royal National Throat Nose and Ear Hospital, London, United Kingdom.
Mark Lowdell6 Institute of Immunity and Transplantation, Centre for Cell, Gene and Tissue Therapeutics, Royal Free Hospital, London, United Kingdom.
Sam M Janes1 Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, University College London, London, United Kingdom.

Funding

Medical Research Council G1001539Medical Research Council MR/L002000/1Medical Research Council MR/R015635/1Wellcome Trust 209199/Z/17/Z
6 · The paper itself

Abstract

impact statementThis article describes a method for engrafting epithelial progenitor cells to a revascularized scaffold in a protective and supportive collagen-rich environment. This method has the potential to overcome two key limitations of existing grafting techniques as epithelial cells are protected from mechanical shear and the relatively hypoxic phase that occurs while grafts revascularize, offering the opportunity to provide epithelial cells to decellularized allografts at the point of implantation. Advances in this area will improve the safety and efficacy of bioengineered organ transplantation.

Indexed as

Stem Cell TransplantationTissue EngineeringAnimalsCell SurvivalChickensChorioallantoic MembraneCollagenEpithelial CellsFibroblastsLungMaleRabbitsStem CellsTissue ScaffoldsTracheaCollagenairway reconstructionepithelial cellsmucosaregenerative medicinetissue engineeringtracheal transplantation

Identifiers

PMID30648458
PMCPMC6389769

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.