Evidence map›Paper›PMID 30648358›Full record

GuidelineCNS neuroscience & therapeutics2019

Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761

Nagaendran Kandiah, Paulus Anam Ong, Turana Yuda, Li-Ling Ng, Kaysar Mamun, Reshma Aziz Merchant, Christopher Chen, Jacqueline Dominguez, Simeon Marasigan, Encarnita Ampil and 10 more

Open access · goldAbstract readPractice GuidelineReviewConsensus Statement
In one paragraph

Guideline in CNS neuroscience & therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 8 pooled it
19.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 8 syntheses or guidelines pooled it, 136 citations in OpenAlex.

  1. Pooled it
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  7. Oxidative medicine and cellular longevity · 2021
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  20. Efficacy ofFrontiers in neurology · 2025
    Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 17 institutions in 8 countries.

Nagaendran KandiahDuke-NUS Singapore, National Neuroscience Institute, Singapore, Singapore.ORCID 0000-0001-9244-4298
Paulus Anam OngHasan Sadikin General Hospital, Bandung, Indonesia.
Turana YudaSchool of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.
Li-Ling NgChangi General Hospital, Singapore, Singapore.
Kaysar MamunSingapore General Hospital, Singapore, Singapore.
Reshma Aziz MerchantDepartment of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-9032-0184
Christopher ChenDepartment of Pharmacology, National University of Singapore, Singapore, Singapore.
Jacqueline DominguezSt Luke's Medical Center, Quezon City, Philippines.
Simeon MarasiganUniversity of Santo Tomas, Metro Manila, Philippines.
Encarnita AmpilUniversity of Santo Tomas, Metro Manila, Philippines.
Van Thong NguyenCan Tho University of Medicine and Pharmacy, Can Tho, Vietnam.
Suraya YusoffHospital Sultan Ismail, Johor, Malaysia.
Yee Fai ChanHospital Kuala Lumpur, Kuala Lumpur, Malaysia.
Fee Mann YongSubang Jaya Medical Centre, Selangor, Malaysia.
Orapitchaya KrairitRamathibodi Hospital, Bangkok, Thailand.
Chuthamanee SuthisisangFaculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Vorapun SenanarongSiriraj Hospital, Bangkok, Thailand.
Yong JiBeijing Tiantan Hospital, Capital Medical University, Beijing, China.
Ramesh ThukralSahara Hospital, Lucknow, India.
Ralf IhlAlexian Hospital, Krefeld, Germany.
National University of Singapore · SGUniversity of Santo Tomas · PHAtma Jaya Catholic University of Indonesia · IDCan Tho University · VNCapital Medical University · CNChangi General Hospital · SGDr. Hasan Sadikin General Hospital · IDDuke-NUS Medical School · SGHospital Kuala Lumpur · MYMahidol University · THRamathibodi Hospital · THSahara Hospital · INSingapore General Hospital · SGSiriraj Hospital · THSt. Luke's Medical Center · PHSubang Jaya Medical Centre · MYSultan Ismail Specialist Hospital · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Ginkgo biloba special extract, EGb 761

methodsTo guide clinical practice in the Asian region, the Asian Clinical Expert Group on Neurocognitive Disorders compiled evidence-based consensus recommendations regarding the use of EGb 761

resultsKey randomized trials and robust meta-analyses have demonstrated significant improvement in cognitive function, neuropsychiatric symptoms, activities of daily living (ADL) and quality of life with EGb 761

conclusionsThe Expert Group foresee an important role for EGb 761

Indexed as

Cerebrovascular DisordersCognitive DysfunctionConsensusDementiaGinkgo bilobaGinkgo ExtractHumansPlant ExtractsRandomized Controlled Trials as TopicGinkgo biloba extractGinkgo ExtractPlant ExtractsAlzheimer diseasecerebrovascular diseasedementiaEGb 761®Ginkgo biloba

Identifiers

PMID30648358
PMCPMC6488894
OpenAlexW2909401811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.