Evidence map›Paper›PMID 30648206›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019

Characteristics of obstructive sleep apnea in myasthenia gravis patients: a single center study.

Sung Jae Heo, Jin-Sun Jun, Donghwi Park, Ho-Won Lee, Jung-Soo Kim, Jin-Sung Park

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. The relationship between obstructive sleep apnea and Parkinson's disease: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sung Jae HeoDepartment of Otorhinolayngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea.
Jin-Sun JunDepartment of Neurology, Kyungpook National University Chilgok Hospital, Daegu, South Korea.
Donghwi ParkDepartment of Rehabilitation, Daegu Fatima Hospital, Daegu, South Korea.
Ho-Won LeeDepartment of Neurology, Kyungpook National University Chilgok Hospital, Daegu, South Korea.
Jung-Soo KimDepartment of Otorhinolayngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea.
Jin-Sung ParkDepartment of Neurology, Kyungpook National University Chilgok Hospital, Daegu, South Korea. neurojspark@gmail.com.ORCID http://orcid.org/0000-0001-5506-9206
Kyungpook National University Hospital · KRKyungpook National University · KRDaegu Fatima Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent studies have shown a high prevalence of obstructive sleep apnea in myasthenia gravis compared to the normal population. The aim of this study was to elucidate clinical and polysomnographic differences between clinically stable Korean MG patients with and without OSA.

methodsA total of 18 consecutively stable MG patients were included in this prospective study. We compared MG patients with OSA (n = 7) and without OSA (n = 11) with respect to the baseline characteristics and overnight polysomnography (PSG) parameters. Demographic parameters, prescribed medication status, thymectomy status, myasthenia gravis foundation of America score, and antibody status were obtained from their medical records. We performed the Korean version of Pittsburg sleep quality index to assess the subjective quality of sleep. Statistical analyses were performed using SPSS version 18.0 with Wilcoxon rank sum test, chi-square test, Fisher's exact test, and Spearman correlation test.

resultsAmong the clinical parameters, MG patients with OSA showed a higher proportion of male sex (p = 0.016) and increased body mass index (p = 0.033). The PSG showed an 11-fold higher supine apnea-hyponea index (AHI) in MG patients with OSA. AHI was further analyzed with supine and non-supine position. MG patients with OSA had a higher supine AHI (19.5 ± 15.8) compared to those without OSA (1.9 ± 1.2, P = 0.008). Most of MG patients with OSA (85.7%) showed more than two times higher supine AHI than non-supine AHI.

conclusionsThis study showed that the occurrence of OSA in patients with MG is associated with male sex and obesity, which is in accordance with the normal population. Moreover, PSG data showed a high prevalence of supine dominant OSA in MG patients with OSA.

Indexed as

Myasthenia GravisOverweightAdultBody Mass IndexComorbidityFemaleHumansMaleMiddle AgedPolysomnographyProspective StudiesRepublic of KoreaSex FactorsSleep Apnea, ObstructiveBody mass indexMaleMyasthenia gravisObstructiveSleep apnea

Identifiers

PMID30648206
OpenAlexW2908975240

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.