ArticleACS central science2018
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
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Article in ACS central science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
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Who cites it
26 citing papers in PubMed.
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- Technology Transfer Magic Sauce Ingredients - When and Where to Use Them.LES nouvelles. Licensing Executives Society (U.S.A.) · 2026Article
- Applications of artificial intelligence in drug discovery for neurological diseases.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products.Natural product reports · 2024Review
- Hilbert-curve assisted structure embedding method.Journal of cheminformatics · 2024Article
- Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products.ACS pharmacology & translational science · 2023Article
- In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.Disease models & mechanisms · 2023Article
- Deciphering and reprogramming the cyclization regioselectivity in bifurcation of indole alkaloid biosynthesis.Chemical science · 2022Article
- MegaSyn: Integrating Generative Molecular Design, Automated Analog Designer, and Synthetic Viability Prediction.ACS omega · 2022Article
- A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model.PloS one · 2022Article
- Kratom Alkaloids as Probes for Opioid Receptor Function: Pharmacological Characterization of Minor Indole and Oxindole Alkaloids from Kratom.ACS chemical neuroscience · 2021Article
- Chemical investigations into the biosynthesis of the gymnastatin and dankastatin alkaloids.Chemical science · 2021Article
- Identification of a Covalent Importin-5 Inhibitor, Goyazensolide, from a Collective Synthesis of Furanoheliangolides.ACS central science · 2021Article
- SANCDB: an update on South African natural compounds and their readily available analogs.Journal of cheminformatics · 2021Article
- Screening for gene expression fluctuations reveals latency-promoting agents of HIV.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Bioactivity Screening and Gene-Trait Matching across Marine Sponge-Associated Bacteria.Marine drugs · 2021Article
- Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Diversification of Nucleophile-Intercepted Beckmann Fragmentation Products and Related Density Functional Theory Studies.The Journal of organic chemistry · 2020Article
- Programmable meroterpene synthesis.Nature communications · 2020Article
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Authors and funding
95 authors.
Sara E KearneyNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Gergely Zahoránszky-KőhalmiNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Kyle R BrimacombeNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Mark J HendersonNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Caitlin LynchNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Tongan ZhaoNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Kanny K WanNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Zina ItkinNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Christopher DillonNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Min ShenNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Dorian M CheffNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Tobie D LeeNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Danielle BougieNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Ken ChengNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Nathan P CoussensNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Dorjbal DorjsurenNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Richard T EastmanNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Ruili HuangNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Michael J IannottiNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Surendra KaravadhiNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Carleen Klumpp-ThomasNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Jacob S RothNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Srilatha SakamuruNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Wei SunNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Steven A TitusNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Adam YasgarNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Ya-Qin ZhangNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Jinghua ZhaoNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Rodrigo B AndradeDepartment of Chemistry, Temple University, 1901 North 13th Street, Philadelphia, Pennsylvania 19122, United States.
M Kevin BrownDepartment of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405, United States.
Noah Z BurnsDepartment of Chemistry, Stanford University, 333 Campus Drive, Stanford, California 94305, United States.
Jin K ChaDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, United States.
Emily E MeversDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, United States.
Jon ClardyDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, United States.
Jason A ClementNatural Products Discovery Institute, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States.
Peter A CrooksUniversity of Arkansas for Medical Sciences, 4301 West Markham Street 522, Little Rock, Arkansas 72205, United States.
Gregory D CunyDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, 4849 Calhoun Road, Houston, Texas 77204, United States.
Jake GanorDiamond Age Corp., 344 East Louisiana Street, McKinney, Texas 75069, United States.
Jesus MorenoDepartment of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.
Lucas A MorrillDepartment of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.
Elias PicazoDepartment of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.
Robert B SusickDepartment of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.
Neil K GargDepartment of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.
Brian C GoessDepartment of Chemistry, Furman University, 3300 Poinsett Highway, Greenville, South Carolina 29613, United States.
Robert B GrossmanDepartment of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.
Chambers C HughesScripps Institution of Oceanography, UCSD, 9500 Gilman Drive, La Jolla, California 92093, United States.
Jeffrey N JohnstonDepartment of Chemistry, Vanderbilt University, 7330 Stevenson Center, Nashville, Tennessee 37235, United States.
Madeleine M JoullieDepartment of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States.
A Douglas KinghornCollege of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, Ohio 43210, United States.
David G I KingstonDepartment of Chemistry, Virginia Tech, 900 West Campus Drive, Blacksburg, Virginia 24061, United States.
Michael J KrischeChemistry Department, The University of Texas at Austin, 105 East 24th Street STOP A5300, Austin, Texas 78712, United States.
Ohyun KwonDepartment of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.
Thomas J MaimoneDepartment of Chemistry, University of California Berkeley, 826 Latimer Hall, Berkeley, California 94720, United States.
Susruta MajumdarDepartment of Molecular Pharmacology and Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.
Katherine N MaloneyDepartment of Chemistry, Point Loma Nazarene University, 3900 Lomaland Drive, San Diego, California 92106, United States.
Enas MohamedUniversity of Mississippi School of Pharmacy, 2500 North State Street, Jackson, Mississippi 39216, United States.
Brian T MurphyCollege of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, Illinois 60607, United States.
Pavel NagornyDepartment of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States.
David E OlsonDepartment of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.
Larry E OvermanDepartment of Chemistry, University of California, Irvine, Irvine, California 92697, United States.
Lauren E BrownDepartment of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
John K SnyderDepartment of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
John A PorcoDepartment of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
Fatima RivasDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, United States.
Samir A RossUniversity of Mississippi School of Pharmacy, 2500 North State Street, Jackson, Mississippi 39216, United States.
Richmond SarpongDepartment of Chemistry, University of California Berkeley, 841-A Latimer Hall, Berkeley, California 94720, United States.
Indrajeet SharmaDepartment of Chemistry and Biochemistry, and Institute of Natural Products and Research Technologies, University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma 73019, United States.
Jared T ShawDepartment of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.
Zhengren XuDepartment of Chemistry, Florida Campus, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States.
Ben ShenDepartment of Chemistry, Florida Campus, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States.
Wei ShiDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas 72701, United States.
Corey R J StephensonDepartment of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States.
Alyssa L VeranoPharmacology Graduate Program, Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.
Derek S TanPharmacology Graduate Program, Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.
Yi TangDepartment of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.
Richard E TaylorDepartment of Chemistry and Biochemistry and the Warren Family Research Center for Drug Discovery and Development, University of Notre Dame, 305 McCourtney Hall, Notre Dame, Indiana 46556, United States.
Regan J ThomsonDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States.
David A VosburgDepartment of Chemistry, Harvey Mudd College, 301 Platt Boulevard, Claremont, California 91711, United States.
Jimmy WuDepartment of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, United States.
William M WuestDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Armen ZakarianSanta Barbara Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States.
Yufeng ZhangSchool of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong SAR.
Tianjing RenSchool of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong SAR.
Zhong ZuoSchool of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong SAR.
James IngleseNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Sam MichaelNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Anton SimeonovNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Wei ZhengNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Paul ShinnNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Ajit JadhavNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Matthew B BoxerNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Matthew D HallNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Menghang XiaNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Rajarshi GuhaNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Jason M RohdeNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MResearch Services Section (RSS)ZICTR000242 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI WILSON, KELLI · 2015 to 2025
$64.9MProject 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI JIMMY ORJALA · 2007 to 2026
$27.2MTHE APOE-APP AXIS IN ALZHEIMER PATHOGENESISP01AG012411 · NIA · UNIV OF ARKANSAS FOR MED SCIS · PI BARGER, STEVEN W · 1995 to 2020
$25.0MDrug Repurposing Screening for Rare and Neglected DiseasesZIATR000018 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI ZHENG, WEI · 2015 to 2025
$24.6MCANCER PHARMACOLOGYT32CA062948 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LORRAINE J GUDAS · 1994 to 2026
$12.1MBIODIVERSITY UTILIZATION IN MADAGASCAR AND SURINAMEU01TW000313 · FIC · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI KINGSTON, DAVID GEORGE IAN · 1993 to 2013
$9.5MChemical Synthesis of Complex Natural Products for Translational ScienceR35GM118173 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI JOHN A. PORCO · 2016 to 2026
$8.2MPhosphine-Catalyzed Annulations and Their ApplicationsR01GM071779 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OHYUN KWON · 2006 to 2026
$5.7MNatural Product-Inspired Approaches Toward The Development Of Antivirulence And Species-Specific InhibitorsR35GM119426 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI William M Wuest · 2016 to 2026
$4.8MStudies in Amide and Peptide SynthesisR01GM063557 · NIGMS · VANDERBILT UNIVERSITY · PI JOHNSTON, JEFFREY NICHOLAS · 2002 to 2022
$4.5MNovel therapeutic agents from the bacterial symbionts of Brazilian invertebratesU19TW009872 · FIC · HARVARD MEDICAL SCHOOL · PI CLARDY, JON, PUPO, MONICA T · 2014 to 2018
$4.4MFIC NIH HHS U01 TW000313FIC NIH HHS U19 TW009872HSRD VA CDP 12-253NCCIH NIH HHS R01 AT008088NCI NIH HHS P01 CA125066NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA078747NCI NIH HHS R01 CA106150NCI NIH HHS R01 CA158275NCI NIH HHS T32 CA062948NHLBI NIH HHS R01 HL025854NIAAA NIH HHS R21 AA026949NIA NIH HHS P01 AG012411NIDA NIH HHS R01 DA046487NIDA NIH HHS R21 DA034106NIDA NIH HHS R21 DA045884NIDA NIH HHS R33 DA045884NIGMS NIH HHS F31 GM117945NIGMS NIH HHS P30 GM103450NIGMS NIH HHS P41 GM076267NIGMS NIH HHS R01 GM030859NIGMS NIH HHS R01 GM063557NIGMS NIH HHS R01 GM071779NIGMS NIH HHS R01 GM084333NIGMS NIH HHS R01 GM110131NIGMS NIH HHS R01 GM111476NIGMS NIH HHS R01 GM114061NIGMS NIH HHS R01 GM114353NIGMS NIH HHS R01 GM115575NIGMS NIH HHS R01 GM116952NIGMS NIH HHS R01 GM121656NIGMS NIH HHS R01 GM126221NIGMS NIH HHS R01 GM129465NIGMS NIH HHS R15 GM116032NIGMS NIH HHS R24 GM111625NIGMS NIH HHS R35 GM118173NIGMS NIH HHS R35 GM119426NIGMS NIH HHS R56 GM063557NINDS NIH HHS R01 NS012389
Abstract
Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds largely or completely untested. To address this issue, the Canvass library of natural products was assembled, in collaboration with academic and industry researchers, for quantitative high-throughput screening (qHTS) across a diverse set of cell-based and biochemical assays. Characterization of the library in terms of physicochemical properties, structural diversity, and similarity to compounds in publicly available libraries indicates that the Canvass library contains many structural elements in common with approved drugs. The assay data generated were analyzed using a variety of quality control metrics, and the resultant assay profiles were explored using statistical methods, such as clustering and compound promiscuity analyses. Individual compounds were then sorted by structural class and activity profiles. Differential behavior based on these classifications, as well as noteworthy activities, are outlined herein. One such highlight is the activity of (-)-2(
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