Evidence map›Paper›PMID 30648146›Full record

ArticleACS central science2018

Bio-Orthogonal Chemistry and Reloadable Biomaterial Enable Local Activation of Antibiotic Prodrugs and Enhance Treatments against

Magdalena Czuban, Sangeetha Srinivasan, Nathan A Yee, Edgar Agustin, Anna Koliszak, Ethan Miller, Irfan Khan, Ilenis Quinones, Hasina Noory, Christopher Motola and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 103 citations in OpenAlex.

  1. Review
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  8. Phage-antibiotic synergy attenuatesFrontiers in cellular and infection microbiology · 2026
    Article
  9. Article
  10. Click-Triggered Bioorthogonal Bond-Cleavage Reactions.Topics in current chemistry (Cham) · 2025
    Review
  11. Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Magdalena CzubanBerlin-Brandenburg Center for Regenerative Therapies and Berlin-Brandenburg School for Regenerative Therapies, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Sangeetha SrinivasanShasqi Inc., 665 Third Street, San Francisco, California 94107, United States.
Nathan A YeeShasqi Inc., 665 Third Street, San Francisco, California 94107, United States.
Edgar AgustinDepartment of Chemistry, University at Albany, 1400 Washington Avenue, Albany, New York 12222, United States.
Anna KoliszakBerlin-Brandenburg Center for Regenerative Therapies, Augustenburger Platz 1, 13353 Berlin, Germany.
Ethan MillerShasqi Inc., 665 Third Street, San Francisco, California 94107, United States.
Irfan KhanDepartment of Chemistry, University at Albany, 1400 Washington Avenue, Albany, New York 12222, United States.
Ilenis QuinonesDepartment of Chemistry, University at Albany, 1400 Washington Avenue, Albany, New York 12222, United States.
Hasina NooryDepartment of Chemistry, University at Albany, 1400 Washington Avenue, Albany, New York 12222, United States.
Christopher MotolaDepartment of Chemistry, University at Albany, 1400 Washington Avenue, Albany, New York 12222, United States.
Rudolf VolkmerInstitute for Medical Immunology and Leibniz-Institut für Molekulare Pharmakologie, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany.
Mariagrazia Di LucaBerlin-Brandenburg Center for Regenerative Therapies, Augustenburger Platz 1, 13353 Berlin, Germany.
Andrej TrampuzCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Center for Musculoskeletal Surgery, Charitéplatz 1, 10117 Berlin, Germany.
Maksim RoyzenDepartment of Chemistry, University at Albany, 1400 Washington Avenue, Albany, New York 12222, United States.
Jose M Mejia OnetoShasqi Inc., 665 Third Street, San Francisco, California 94107, United States.
University at Albany, State University of New York · USBerlin-Brandenburger Centrum für Regenerative Therapien · DEHumboldt-Universität zu Berlin · DELeibniz-Forschungsinstitut für Molekulare Pharmakologie · DE

Funding

Development of Catch and Release Approach for Multi-Drug Local Delivery of ChemotherapiesR21CA228997 · NCI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI ROYZEN, MAKSIM · 2018 to 2020
$606k
Using implantable biomaterial and bio-orthogonal chemistry to guide delivery of antibioticsR43GM119864 · NIGMS · TAMBO, INC. · PI MEJIA ONETO, JOSE M · 2016 to 2016
$225k
NCI NIH HHS R21 CA228997NIGMS NIH HHS R43 GM119864
6 · The paper itself

Abstract

Systemic administration of antibiotics can cause severe side-effects such as liver and kidney toxicity, destruction of healthy gut bacteria, as well as multidrug resistance. Here, we present a bio-orthogonal chemistry-based strategy toward local prodrug concentration and activation. The strategy is based on the inverse electron-demand Diels-Alder chemistry between

Identifiers

PMID30648146
PMCPMC6311693
OpenAlexW2904593458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.