Evidence map›Paper›PMID 30647817›Full record

ArticleOxidative medicine and cellular longevity2018

Comparison of Cardiac miRNA Transcriptomes Induced by Diabetes and Rapamycin Treatment and Identification of a Rapamycin-Associated Cardiac MicroRNA Signature.

Anthony M Belenchia, Madhavi P Gavini, Ryan G Toedebusch, Vincent G DeMarco, Lakshmi Pulakat

Abstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. How to measure and model cardiovascular aging.Cardiovascular research · 2025
    Review
  2. Review
  3. Article
  4. Article
  5. Four-microRNA signature for detection of type 2 diabetes.World journal of clinical cases · 2020
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anthony M BelenchiaDalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA.
Madhavi P GaviniNovopyxis, Boston, MA, USA.
Ryan G ToedebuschDalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA.
Vincent G DeMarcoDepartment of Medicine, University of Missouri, Columbia, MO, USA.
Lakshmi PulakatDalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA.ORCID 0000-0002-1430-2945

Funding

Mechanisms for Sex Differences in CVD Pathology and Development of a Targeted TherapeuticR01HL138988 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI JAFFE, IRIS Z, PULAKAT, LAKSHMIDEVI · 2018 to 2021
$2.6M
The mTORCI-miR-29-AT2R axis in cardiovascular diseasesR01HL118376 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI PULAKAT, LAKSHMIDEVI · 2013 to 2017
$2.0M
NHLBI NIH HHS R01 HL118376NHLBI NIH HHS R01 HL138988
6 · The paper itself

Abstract

Rapamycin (Rap), an inhibitor of mTORC1, reduces obesity and improves lifespan in mice. However, hyperglycemia and lipid disorders are adverse side effects in patients receiving Rap treatment. We previously reported that diabetes induces pansuppression of cardiac cytokines in Zucker obese rats (ZO-C). Rap treatment (750

Indexed as

AnimalsDiabetes MellitusDisease Models, AnimalHumansMaleMicroRNAsRatsRats, ZuckerSirolimusTranscriptomeMicroRNAsSirolimus

Identifiers

PMID30647817
PMCPMC6311877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.