Evidence map›Paper›PMID 30647810›Full record

ReviewOxidative medicine and cellular longevity2018

Oxidative Stress in Poultry: Lessons from the Viral Infections.

Zaib Ur Rehman, Chunchun Meng, Yingjie Sun, Anum Safdar, Riaz Hussain Pasha, Muhammad Munir, Chan Ding

Open access · hybridAbstract readReview
In one paragraph

Review in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 77 citations in OpenAlex.

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  8. Effects of Different Levels ofAntioxidants (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Zaib Ur RehmanShanghai Veterinary Research Institute (SHVRI), Chinese Academy of Agricultural Sciences (CAAS), Shanghai 200241, China.ORCID 0000-0002-8109-797X
Chunchun MengShanghai Veterinary Research Institute (SHVRI), Chinese Academy of Agricultural Sciences (CAAS), Shanghai 200241, China.
Yingjie SunShanghai Veterinary Research Institute (SHVRI), Chinese Academy of Agricultural Sciences (CAAS), Shanghai 200241, China.
Anum SafdarShanghai Veterinary Research Institute (SHVRI), Chinese Academy of Agricultural Sciences (CAAS), Shanghai 200241, China.
Riaz Hussain PashaDepartment of Veterinary Biomedical Sciences, Faculty of Veterinary and Animal Sciences, PMAS Arid Agriculture University, Rawalpindi 46300, Pakistan.
Muhammad MunirBiomedical and Life Sciences, Lancaster University, Lancaster LA1 4YG, UK.ORCID 0000-0002-7889-1398
Chan DingShanghai Veterinary Research Institute (SHVRI), Chinese Academy of Agricultural Sciences (CAAS), Shanghai 200241, China.ORCID 0000-0003-0216-2129
Shanghai Veterinary Research Institute · CNPir Mehr Ali Shah Arid Agriculture University · PKLancaster University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactive species (RS), generally known as reactive oxygen species (ROS) and reactive nitrogen species (RNS), are produced during regular metabolism in the host and are required for many cellular processes such as cytokine transcription, immunomodulation, ion transport, and apoptosis. Intriguingly, both RNS and ROS are commonly triggered by the pathogenic viruses and are famous for their dual roles in the clearance of viruses and pathological implications. Uncontrolled production of reactive species results in oxidative stress and causes damage in proteins, lipids, DNA, and cellular structures. In this review, we describe the production of RS, their detoxification by a cellular antioxidant system, and how these RS damage the proteins, lipids, and DNA. Given the widespread importance of RS in avian viral diseases, oxidative stress pathways are of utmost importance for targeted therapeutics. Therefore, a special focus is provided on avian virus-mediated oxidative stresses. Finally, future research perspectives are discussed on the exploitation of these pathways to treat viral diseases of poultry.

Indexed as

AnimalsChickensHumansOxidative StressPoultryReactive Nitrogen SpeciesReactive Oxygen SpeciesVirus DiseasesReactive Nitrogen SpeciesReactive Oxygen Species

Identifiers

PMID30647810
PMCPMC6311761
OpenAlexW2904741920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.