ReviewJournal of biological engineering2019
Follicle development as an orchestrated signaling network in a 3D organoid.
Review in Journal of biological engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 98 citations in OpenAlex.
- Scaffold-based biomaterials in ovarian tissue engineering.RSC advances · 2026Review
- Optimization of Sodium Alginate Concentration and Evaluation of Individual Versus Group In Vitro Culture of Porcine Preantral Follicles in a Serum-Free Medium.Animals : an open access journal from MDPI · 2026Article
- In Vitro Development of Primordial Follicles from Human Ovarian Tissue.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Expression of New Gene Markers Regulating Protein Metabolism in Porcine Ovarian Granulosa Cells In Vitro.International journal of molecular sciences · 2025Article
- Transcriptome Sequencing and Differential Analysis of Ovaries Across Diverse States (Follicular and Non-Follicular Phases).Animals : an open access journal from MDPI · 2025Article
- Folliculogenesis: A Cellular Crosstalk Mechanism.Current issues in molecular biology · 2025Review
- Transcriptomic effects of alginate hydrogel applied to the production of bovine embryos.Heliyon · 2024Article
- New Insights on In Vitro Maturation of Oocytes for Fertility Preservation.International journal of molecular sciences · 2024Review
- Article
- Quantification of follicles in human ovarian tissue using image processing software and trained artificial intelligence†.Biology of reproduction · 2024Article
- Article
- Mesenchymal stem cells promote ovarian reconstruction in mice.Stem cell research & therapy · 2024Article
- Cellular atlas of the human ovary using morphologically guided spatial transcriptomics and single-cell sequencing.Science advances · 2024Article
- Interleukin-6 Concentration in Single-Embryo Medium Is Associated with Blastocyst Formation.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- In Vitro Growth of Human Follicles: Current and Future Perspectives.International journal of molecular sciences · 2024Review
- 3D culture applied to reproduction in females: possibilities and perspectives.Animal reproduction · 2024Review
- Making a good egg: human oocyte health, aging, and in vitro development.Physiological reviews · 2023Review
- Co-culture of human cryopreserved fragmented ovarian tissue with theca progenitor cells derived from theca stem cells.Journal of assisted reproduction and genetics · 2023Article
- Oocyte Cryopreservation for Medical and Planned Indications: A Practical Guide and Overview.Journal of clinical medicine · 2023Review
- Bone Morphogenetic Protein 15 (BMP-15) Improves In Vitro Mouse Folliculogenesis.Animals : an open access journal from MDPI · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The ovarian follicle is the structural and functional unit of the ovary, composed of the female gamete (the oocyte) and supportive somatic cells. Follicles are not only the source of a female's germ cell supply, but also secrete important hormones necessary for proper endocrine function. Folliculogenesis, the growth and maturation of the follicular unit, is a complex process governed by both intrafollicular crosstalk and pituitary-secreted hormones. While the later stages of this process are gonadotropin-dependent, early folliculogenesis appears to be controlled by the ovarian microenvironment and intrafollicular paracrine and autocrine signaling. In vitro follicle culture remains challenging because of the limited knowledge of growth factors and other cytokines influencing early follicle growth. Here we discuss the current state of knowledge on paracrine and autocrine signaling influencing primary follicles as they develop into the antral stage. Given the importance of intrafollicular signaling and the ovarian microenvironment, we reviewed the current engineering approaches for in vitro follicle culture, including 3D systems using natural hydrogels such as alginate and synthetic hydrogels such as poly(ethylene glycol). Our discussion is focused on what drives the proliferation of granulosa cells, development of the thecal layer, and antrum formation-three processes integral to follicle growth up to the antral stage. Further research in this area may reveal the mechanisms behind these complex signaling relationships within the follicle, leading to more successful and physiologically-relevant in vitro culture methods that will translate well to clinical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.