Evidence map›Paper›PMID 30647449›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019

A novel GPR55-mediated satiety signal in the oval Bed Nucleus of the Stria Terminalis.

E R Hawken, C P Normandeau, J Gardner Gregory, B Cécyre, J-F Bouchard, K Mackie, É C Dumont

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Amylin as a Future Obesity Treatment.Journal of obesity & metabolic syndrome · 2021
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

E R HawkenDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
C P NormandeauDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
J Gardner GregoryDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
B CécyreÉcole d'optométrie, Université de Montréal, Montréal, QC, Canada.
J-F BouchardÉcole d'optométrie, Université de Montréal, Montréal, QC, Canada.
K MackieGill Center for Biomolecular Science, Indiana University, Bloomington, Indiana, USA.
É C DumontDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada. eric.dumont@queensu.ca.
Queen's University · CAUniversité de Montréal · CAIndiana University Bloomington · US

Funding

Cannabinoid Modulation of Cell FunctionK05DA021696 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI MACKIE, KENNETH · 2007 to 2017
$1.3M
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) DA021696Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) 338319Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) MFE-123712Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) MOP-25953Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT-156029Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada) 201411DVC-347523-257929Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada) RGPAS 478115-2015/RGPIN 2015-06582NIDA NIH HHS K05 DA021696
6 · The paper itself

Abstract

Nestled within feeding circuits, the oval (ov) region of the Bed Nucleus of the Stria Terminalis (BNST) may be critical for monitoring energy balance through changes in synaptic strength. Here we report that bidirectional plasticity at ovBNST GABA synapses was tightly linked to the caloric state of male rats, seesawing between long-term potentiation (iLTP, fed) and depression (iLTD, food restricted). L-α-lysophosphatidylinositol (LPI) acting on GPR55 receptors and 2-arachidonoylglycerol (2-AG) through CB1R were respectively responsible for fed (iLTP) and food restricted (iLTD) states. Thus, we have characterized a potential gating mechanism within the ovBNST that may signal metabolic state within the rat brain feeding circuitry.

Indexed as

Neuronal PlasticityAnimalsgamma-Aminobutyric AcidGene Knockout TechniquesInhibitory Postsynaptic PotentialsMaleMice, Inbred C57BLRats, Long-EvansReceptor, Cannabinoid, CB1Receptors, CannabinoidReceptors, G-Protein-CoupledSatiety ResponseSeptal NucleiSynapsesgamma-Aminobutyric AcidGPR55 protein, ratReceptor, Cannabinoid, CB1Receptors, CannabinoidReceptors, G-Protein-Coupled

Identifiers

PMID30647449
PMCPMC6785105
OpenAlexW2907661848

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.