ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
Insulin modulates the strong reinforcing effects of nicotine and changes in insulin biomarkers in a rodent model of diabetes.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- The influence of high-fat diet on nicotine vapor self-administration, neuronal excitability, and leptin levels in adult mice.Physiology & behavior · 2025Article
- Acute nicotine intake increases feeding behavior through decreasing glucagon signaling in dependent male and female rats.Hormones and behavior · 2024Article
- Effectiveness of pharmacotherapies for diabetes on nicotine, food, and water intake in insulin-resistant rats.Advances in drug and alcohol research · 2023Article
- The emergence of insulin resistance following a chronic high-fat diet regimen coincides with an increase in the reinforcing effects of nicotine in a sex-dependent manner.Neuropharmacology · 2021Article
- Vitamin D3 attenuates oxidative stress and regulates glucose level and leukocyte count in a semi-chronic streptozotocin-induced diabetes model.Journal of diabetes and metabolic disorders · 2021Article
- Insulin restores the neurochemical effects of nicotine in the mesolimbic pathway of diabetic rats.Journal of neurochemistry · 2021Article
- Examination of nicotine and saccharin reward in the Goto-Kakizaki diabetic rat model.Neuroscience letters · 2020Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
This study examined whether the strong reinforcing effects of nicotine and changes in insulin biomarkers observed in diabetic rats are modulated via insulin. A model of diabetes was employed involving administration of streptozotocin (STZ), which produces hypoinsulinemia in rats. The present study included vehicle- or STZ-treated rats that received sham surgery or insulin pellets. Two weeks later, the rats were given extended access to intravenous self-administration (IVSA) of saline or nicotine. Concomitant changes in food intake, water responses, and body weight were assessed during 12 days of IVSA. After the last session, plasma levels of insulin, leptin, amylin, and glucagon-like peptide-1 (GLP-1) were assessed using Luminex
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