Evidence map›Paper›PMID 30647150›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Knockdown of Fidgetin Improves Regeneration of Injured Axons by a Microtubule-Based Mechanism.

Andrew J Matamoros, Veronica J Tom, Di Wu, Yash Rao, David J Sharp, Peter W Baas

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Regulation of axonal regeneration after mammalian spinal cord injury.Nature reviews. Molecular cell biology · 2023
    Review
  9. Review
  10. Article
  11. Article
  12. The Role of Spastin in Axon Biology.Frontiers in cell and developmental biology · 2022
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Andrew J MatamorosDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, and.ORCID 0000-0001-6370-5049
Veronica J TomDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, and.ORCID 0000-0002-3369-7575
Di WuDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, and.
Yash RaoDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, and.
David J SharpAlbert Einstein College of Medicine, Department of Physiology and Biophysics, Bronx, New York 10461.
Peter W BaasDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, and pwb22@drexel.edu.ORCID 0000-0002-1272-4538
Drexel University · USAlbert Einstein College of Medicine · US

Funding

MICROTUBULE DYNAMICS AND AXON GROWTHR01NS028785 · NINDS · UNIVERSITY OF WISCONSIN MADISON · PI BAAS, PETER W. · 1990 to 2021
$7.3M
Multipronged approach to promote functional axonal regeneration in the spinal cord after injuryR01NS085426 · NINDS · DREXEL UNIVERSITY · PI TOM, VERONICA JEAN · 2014 to 2024
$3.6M
Soluble TNFa in the development of autonomic dysreflexia after spinal cord injuryR01NS106908 · NINDS · DREXEL UNIVERSITY · PI BETHEA, JOHN ROLAND, TOM, VERONICA JEAN · 2018 to 2022
$2.9M
Cellular Remodeling by Microtubule SeveringR01GM109909 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ROSS, JENNIFER L, SHARP, DAVID JAMES · 2014 to 2017
$1.2M
Microtubule-mediated nerve regeneration: Knocking down fidgetin, a microtubule severing protein, augments microtubule mass and axon regeneration.F31NS103443 · NINDS · DREXEL UNIVERSITY · PI MATAMOROS, ANDREW · 2018 to 2018
$34k
NIGMS NIH HHS R01 GM109909NINDS NIH HHS F31 NS103443NINDS NIH HHS R01 NS028785NINDS NIH HHS R01 NS085426NINDS NIH HHS R01 NS106908
6 · The paper itself

Abstract

Fidgetin is a microtubule-severing protein that pares back the labile domains of microtubules in the axon. Experimental depletion of fidgetin results in elongation of the labile domains of microtubules and faster axonal growth. To test whether

Indexed as

AggrecansAnimalsATPases Associated with Diverse Cellular ActivitiesAxonsFemaleGanglia, SpinalGene Knockdown TechniquesMaleMice, TransgenicMicrotubule-Associated ProteinsMicrotubulesNerve RegenerationNeurogliaNuclear ProteinsRats, Sprague-DawleyAcan protein, mouseAggrecansATPases Associated with Diverse Cellular ActivitiesFign protein, mouseMicrotubule-Associated ProteinsNuclear ProteinsaxonDRGfidgetinmicrotubuleregeneration

Identifiers

PMID30647150
PMCPMC6507085
OpenAlexW2910224576

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.