ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Neurons in FEF Keep Track of Items That Have Been Previously Fixated in Free Viewing Visual Search.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Role of neuronal oscillations in memory driven visual processing.BMC biology · 2026Article
- The Visual Umwelt of primates and Hippocampal Representations of Space.Hippocampus · 2026Review
- Compositional architecture: Orthogonal neural codes for task context and spatial memory in prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Refixation behavior in naturalistic viewing: Methods, mechanisms, and neural correlates.Attention, perception & psychophysics · 2025Review
- Feature-selective responses in macaque visual cortex follow eye movements during natural vision.Nature neuroscience · 2024Article
- Intracortical recordings reveal vision-to-action cortical gradients driving human exogenous attention.Nature communications · 2024Article
- Inhibitory tagging both speeds and strengthens saccade target selection in the superior colliculus during visual search.Journal of neurophysiology · 2024Article
- Inhibitory tagging in the superior colliculus during visual search.Journal of neurophysiology · 2023Article
- The roles of the lateral intraparietal area and frontal eye field in guiding eye movements in free viewing search behavior.Journal of neurophysiology · 2021Article
- Neural mechanism of priming in visual search.Attention, perception & psychophysics · 2021Review
- Modeling the effects of perisaccadic attention on gaze statistics during scene viewing.Communications biology · 2020Article
- The functional roles of neural remapping in cortex.Journal of vision · 2020Article
- Behavioral and neuronal study of inhibition of return in barn owls.Scientific reports · 2020Article
- Eye movement characteristics in schizophrenia: A recent update with clinical implications.Neuropsychopharmacology reports · 2020Review
- What Neuroscientific Studies Tell Us about Inhibition of Return.Vision (Basel, Switzerland) · 2019Review
- Salience Models: A Computational Cognitive Neuroscience Review.Vision (Basel, Switzerland) · 2019Review
- Ketamine-Induced Alteration of Working Memory Utility during Oculomotor Foraging Task in Monkeys.eNeuroArticle
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
When searching a visual scene for a target, we tend not to look at items or locations we have already searched. It is thought that this behavior is driven by an inhibitory tagging mechanism that inhibits responses on priority maps to the relevant items. We hypothesized that this inhibitory tagging signal should be represented as an elevated response in neurons that keep track of stimuli that have been fixated. We recorded from 231 neurons in the frontal eye field (FEF) of 2 male animals performing a visual foraging task, in which they had to find a reward linked to one of five identical targets (Ts) among five distractors. We identified 38 neurons with activity that was significantly greater when the stimulus in the receptive field had been fixated previously in the trial than when it had not been fixated. The response to a fixated object began before the saccade ended, suggesting that this information is remapped. Unlike most FEF neurons, the activity in these cells was not suppressed during active fixation, had minimal motor responses, and did not change through the trial. Yet using traditional classifications from a memory-guided saccade, they were indistinguishable from the rest of the FEF population. We propose that these neurons keep track of any items that have been fixated within the trial and this signal is propagated by remapping. These neurons could be the source of the inhibitory tagging signal to parietal cortex, where a neuronal instantiation of inhibitory tagging is seen.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.