ArticleClinical chemistry2019
Validation of a Metabolite Panel for a More Accurate Estimation of Glomerular Filtration Rate Using Quantitative LC-MS/MS.
Article in Clinical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Evaluation of equation as a classifier for kidney function in domestic cats: a proof-of-concept study.npj aging · 2026Article
- Serum metabolomics identifies gut-derived uremic toxins and bile acid dysregulation associated with chronic kidney disease severity.Scientific reports · 2026Article
- Quantitative Analysis of a Novel Metabolite Panel to Estimate GFR (Panel eGFR) in Serum and Plasma Using LC-MS/MS.Clinical chemistry · 2025Article
- Development and Validation of an Accurate Creatinine-Based Equation to Estimate Glomerular Filtration Rate for the Adult Indian Population: Design and Methods.Indian journal of nephrology · 2024Article
- Accuracy of glomerular filtration rate estimation using creatinine and cystatin C for identifying and monitoring moderate chronic kidney disease: the eGFR-C study.Health technology assessment (Winchester, England) · 2024Article
- Consistency of metabolite associations with measured glomerular filtration rate in children and adults.Clinical kidney journal · 2024Article
- Evaluation of novel candidate filtration markers from a global metabolomic discovery for glomerular filtration rate estimation.Kidney international · 2024Article
- Nontargeted Plasma Proteomic Analysis of Renal Disease and Pulmonary Hypertension in Patients with Sickle Cell Disease.Journal of proteome research · 2024Article
- Panel estimated Glomerular Filtration Rate (GFR): Statistical considerations for maximizing accuracy in diverse clinical populations.PloS one · 2024Article
- Metabolite profiling of CKD progression in the chronic renal insufficiency cohort study.JCI insight · 2022Article
- Serum Orotidine: A Novel Biomarker of Increased CVD Risk in Type 2 Diabetes Discovered Through Metabolomics Studies.Diabetes care · 2022Article
- Analytical Validation of GFRDiagnostics (Basel, Switzerland) · 2022Article
- Measured Glomerular Filtration Rate: The Query for a Workable Golden Standard Technique.Journal of personalized medicine · 2021Review
- Serum Myo-Inositol, Dimethyl Sulfone, and Valine in Combination with Creatinine Allow Accurate Assessment of Renal Insufficiency-A Proof of Concept.Diagnostics (Basel, Switzerland) · 2021Article
- Article
- Global biochemical analysis of plasma, serum and whole blood collected using various anticoagulant additives.PloS one · 2021Article
- Cystatin C as a biomarker of chronic kidney disease: latest developments.Expert review of molecular diagnostics · 2020Review
- Measured and estimated glomerular filtration rate: current status and future directions.Nature reviews. Nephrology · 2020Review
- Article
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18 authors.
Funding
Abstract
backgroundClinical practice guidelines recommend estimation of glomerular filtration rate (eGFR) using validated equations based on serum creatinine (eGFRcr), cystatin C (eGFRcys), or both (eGFRcr-cys). However, when compared with the measured GFR (mGFR), only eGFRcr-cys meets recommended performance standards. Our goal was to develop a more accurate eGFR method using a panel of metabolites without creatinine, cystatin C, or demographic variables.
methodsAn ultra-performance liquid chromatography-tandem mass spectrometry assay for acetylthreonine, phenylacetylglutamine, pseudouridine, and tryptophan was developed, and a 20-day, multiinstrument analytical validation was conducted. The assay was tested in 2424 participants with mGFR data from 4 independent research studies. A new GFR equation (eGFRmet) was developed in a random subset (n = 1615) and evaluated in the remaining participants (n = 809). Performance was assessed as the frequency of large errors [estimates that differed from mGFR by at least 30% (1 - P
resultsThe assay had a mean imprecision (≤10% intraassay, ≤6.9% interassay), linearity over the quantitative range (
conclusionsThe new eGFRmet equation could serve as a confirmatory test for GFR estimation.
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