Evidence map›Paper›PMID 30647105›Full record

ArticleG3 (Bethesda, Md.)2019

Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Bashar Alhoch, Alan Chen, Elaine Chan, Asmaa Elkabti, Sasha Fariña, Catherine Gilbert, Jean Kang, Bradley King, Karen Leung, Julia Levy and 16 more

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 3 institutions in 1 country.

Bashar AlhochW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711.
Alan ChenW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711.
Elaine ChanW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711.
Asmaa ElkabtiW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711.ORCID 0000-0002-3254-207X
Sasha FariñaW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711.
Catherine GilbertW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711.ORCID 0000-0002-6027-8472
Jean KangW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711.
Bradley KingMolecular Biology Program, Pomona College, Claremont, CA 91711.
Karen LeungW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711.
Julia LevyW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711.
Elizabeth MartinW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711.
Benjamin MazerMolecular Biology Program, Pomona College, Claremont, CA 91711.
Sara McKinneyW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711.
Alexandra MoyzisW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711.
Margaret NurimbaW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711.
Michelle OzakiW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711.
Kathleen Purvis-RobertsW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711.ORCID 0000-0003-1723-5968
Joshua Marc RothmanMolecular Biology Program, Pomona College, Claremont, CA 91711.
Shravya RajuW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711.
Cynthia SelassieChemistry Department, Pomona College, Claremont, CA 91711.ORCID 0000-0002-7832-3331
Oliver SmithW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711.
Julia TicusMolecular Biology Program, Pomona College, Claremont, CA 91711.
Gretchen Edwalds-GilbertW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711 gedwalds@kecksci.claremont.edu ztang@kecksci.claremont.edu Tina.Negritto@pomona.edu ruye_wang@hmc.edu.ORCID 0000-0002-6027-8472
M Cristina NegrittoMolecular Biology Program, Pomona College, Claremont, CA 91711 gedwalds@kecksci.claremont.edu ztang@kecksci.claremont.edu Tina.Negritto@pomona.edu ruye_wang@hmc.edu.ORCID 0000-0002-3896-0694
Ruye WangEngineering Department, Harvey Mudd College, Claremont, CA 91711 gedwalds@kecksci.claremont.edu ztang@kecksci.claremont.edu Tina.Negritto@pomona.edu ruye_wang@hmc.edu.
Zhaohua TangW.M. Keck Science Department, The Claremont Colleges, Claremont, CA 91711 gedwalds@kecksci.claremont.edu ztang@kecksci.claremont.edu Tina.Negritto@pomona.edu ruye_wang@hmc.edu.ORCID 0000-0002-0253-5194
Claremont Colleges · USPomona College · USHarvey Mudd College · US

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Living organisms encounter various perturbations, and response mechanisms to such perturbations are vital for species survival. Defective stress responses are implicated in many human diseases including cancer and neurodegenerative disorders. Phenol derivatives, naturally occurring and synthetic, display beneficial as well as detrimental effects. The phenol derivatives in this study, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), and bisphenol A (BPA), are widely used as food preservatives and industrial chemicals. Conflicting results have been reported regarding their biological activity and correlation with disease development; understanding the molecular basis of phenol action is a key step for addressing issues relevant to human health. This work presents the first comparative genomic analysis of the genetic networks for phenol stress response in an evolutionary context of two divergent yeasts,

Indexed as

Gene Regulatory NetworksBenzhydryl CompoundsBisphenol A CompoundsButylated HydroxyanisoleButylated HydroxytolueneCell Cycle CheckpointsDNA RepairEndoplasmic Reticulum StressGenomicsPhenolsReactive Oxygen SpeciesSaccharomyces cerevisiaeSchizosaccharomycesUnfolded Protein ResponseBenzhydryl Compoundsbisphenol ABisphenol A CompoundsButylated HydroxyanisoleButylated HydroxytoluenePhenolsReactive Oxygen Speciescell cycle regulation and DNA repaircomparative genomic screenergosterol and V-ATPasephenol stress response in yeastsUPR

Identifiers

PMID30647105
PMCPMC6404616
OpenAlexW2909638471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.