Evidence map›Paper›PMID 30646968›Full record

ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2019

Chemical Contaminants from Plastics in the Animal Environment.

Galen J Gorence, Hannah C Pulcastro, Crystal A Lawson, Roy R Gerona, Matthew Friesen, Tegan S Horan, Mary C Gieske, Caroline V Sartain, Patricia A Hunt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Galen J GorenceVivarium Services, Office of the Campus Veterinarian, Washington State University, Pullman, Washington, USA.
Hannah C PulcastroSchool of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, Washington, USA.
Crystal A LawsonSchool of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, Washington, USA.
Roy R GeronaSchool of Medicine, University of California, San Francisco, California, USA.
Matthew FriesenSchool of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, Washington, USA.
Tegan S HoranSchool of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, Washington, USA.
Mary C GieskeSchool of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, Washington, USA.
Caroline V SartainSchool of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, Washington, USA.
Patricia A HuntSchool of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, Washington, USA. pathunt@wsu.edu.
Washington State University · USUniversity of California, San Francisco · US

Funding

Meiotic Studies of Chemicals With Estrogenic ActivityR01ES013527 · NIEHS · WASHINGTON STATE UNIVERSITY · PI HUNT, PATRICIA · 2005 to 2014
$4.5M
Male Germline Development and Estrogenic ExposuresR01HD083177 · NICHD · WASHINGTON STATE UNIVERSITY · PI HUNT, PATRICIA · 2015 to 2019
$1.7M
Meiotic Studies of Chemicals with Estrogenic ActivityR56ES013527 · NIEHS · WASHINGTON STATE UNIVERSITY · PI GERONA, ROY ROBERTO R, HUNT, PATRICIA · 2017 to 2017
$250k
Mechanisms of Bisphenol A Effects on Female MeiosisF32ES026010 · NIEHS · WASHINGTON STATE UNIVERSITY · PI SARTAIN, CAROLINE · 2015 to 2016
$92k
NICHD NIH HHS R01 HD083177NIEHS NIH HHS F32 ES026010NIEHS NIH HHS R01 ES013527NIEHS NIH HHS R56 ES013527
6 · The paper itself

Abstract

Accidental exposure of our mice to bisphenol A (BPA) from damaged polycarbonate cages 20 y ago provided some of the first evidence of the harmful effects of exposure to this common chemical. Recently we found that housing mice in damaged polysulfone cages resulted in similar harmful effects due to exposure to bisphenol S (BPS). This problem was unexpected for 2 reasons. First, polysulfone is a far more chemically resistant polymer than polycarbonate. Second, BPS is not a component in the manufacture of polysulfone. We report here our efforts to verify the source of the BPS and eliminate the exposure. Our analysis of new polysulfone caging materials confirmed that BPS is a breakdown product of damaged polysulfone plastic. Furthermore, we found that BPS can cross-contaminate new or undamaged cages in facilities that process damaged caging materials. Neither the use of disposable cages nor replacement of caging materials used solely for our colony was sufficient to eliminate exposure effects. Only the replacement of all cages and water bottles in the facility corrected the problem and allowed us to resume our studies. Taken together, our previous and current findings underscore the concern that chemicals from plastics are harmful environmental contaminants for both humans and animals. Furthermore, our results provide strong evidence that the presence of damaged plastic in a facility may be sufficient to affect research results and, by exten- sion, animal health.

Indexed as

Housing, AnimalAnimalsEnvironmental ExposureHumansLaboratory Animal ScienceMicePlasticsPolymersSulfonesPlasticsPolymerspolysulfone P 1700Sulfones

Identifiers

PMID30646968
PMCPMC6433350
OpenAlexW2909238119

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.