Evidence map›Paper›PMID 30646960›Full record

ArticleStem cell research & therapy2019

DP71 and SERCA2 alteration in human neurons of a Duchenne muscular dystrophy patient.

Simona Ruggieri, Luigi Viggiano, Tiziana Annese, Carmela Rubolino, Andrea Gerbino, Roberta De Zio, Patrizia Corsi, Roberto Tamma, Domenico Ribatti, Mariella Errede and 7 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Neuromuscular Development and Disease: Learning FromFrontiers in cell and developmental biology · 2021
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Simona RuggieriDepartment of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.
Luigi ViggianoDepartment of Biology, University of Bari, Bari, Italy. luigi.viggiano@uniba.it.
Tiziana AnneseDepartment of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.
Carmela RubolinoDepartment of Biology, University of Bari, Bari, Italy.
Andrea GerbinoDepartment of Bioscience, Biotechnology and Biopharmaceutics, University of Bari, Bari, Italy.
Roberta De ZioDepartment of Bioscience, Biotechnology and Biopharmaceutics, University of Bari, Bari, Italy.
Patrizia CorsiDepartment of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.
Roberto TammaDepartment of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.
Domenico RibattiDepartment of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.
Mariella ErredeDepartment of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.
Francesca OpertoDepartment of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.
Lucia MargariDepartment of Biomedical Sciences and Human Oncology, Unit of Internal Medicine "Guido Baccelli", University of Bari Medical School, Bari, Italy.
Nicoletta RestaDivision of Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari Medical School, Bari, Italy.
Silvia Di TommasoDivision of Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari Medical School, Bari, Italy.
Jessica RosatiCellular Reprogramming Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Maria TrojanoDepartment of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.
Beatrice NicoDepartment of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy. beatrice.nico@uniba.it.
University of Bari Aldo Moro · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive deficit has been identified in one third of patients affected by Duchenne Muscular Dystrophy, primarily attributed to loss of the short Dp71 dystrophin, the major brain dystrophin isoform. In this study, we investigated for the first time the Dp71 and Dp71-associated proteins cellular localization and expression in human neurons obtained by differentiation from induced pluripotent stem cell line of a patient affected by cognitive impairment. We found structural and molecular alterations in both pluripotent stem cell and derived neurons, reduced Dp71 expression, and a Ca

Indexed as

AdultCell DifferentiationCognitive DysfunctionDystrophinHumansMaleMuscular Dystrophy, DuchenneNeuronsSarcoplasmic Reticulum Calcium-Transporting ATPasesYoung Adultapo-dystrophin 1ATP2A2 protein, humanDystrophinSarcoplasmic Reticulum Calcium-Transporting ATPasesDp71 dystrophinDuchenne muscular dystrophyhiPSCsNeuronsPluripotent stem cellSERCA2

Identifiers

PMID30646960
PMCPMC6334379
OpenAlexW2910818528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.