Evidence map›Paper›PMID 30646942›Full record

Trial reportArthritis research & therapy2019

Association between IL23R and ERAP1 polymorphisms and sacroiliac or spinal MRI inflammation in spondyloarthritis: DESIR cohort data.

Adeline Ruyssen-Witrand, Cécile Luxembourger, Alain Cantagrel, Delphine Nigon, Pascal Claudepierre, Yannick Degboe, Arnaud Constantin

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Arthritis research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  8. Effect ofArchives of Razi Institute · 2022
    Article
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  10. The Association Study ofFrontiers in neuroscience · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Adeline Ruyssen-WitrandCentre de rhumatologie, CHU de Toulouse, UMR 1027, Inserm, Université Paul Sabatier Toulouse III, Toulouse, France. ruyssen-witrand.a@chu-toulouse.fr.ORCID 0000-0002-9815-2138
Cécile LuxembourgerCentre de rhumatologie, CHU de Toulouse, UMR 1027, Inserm, Université Paul Sabatier Toulouse III, Toulouse, France.
Alain CantagrelCentre de rhumatologie, CHU de Toulouse, UMR 1043, CPTP, Inserm, Université Paul Sabatier Toulouse III, Toulouse, France.
Delphine NigonCentre de rhumatologie, CHU de Toulouse, Toulouse, France.
Pascal ClaudepierreDepartement de Rhumatologie, Henri Mondor Hospital, APHP, Université Paris Est Créteil, EA 7379 - EpidermE, F-94010, Créteil, France.
Yannick DegboeCentre de rhumatologie, CHU de Toulouse, UMR 1043, CPTP, Inserm, Université Paul Sabatier Toulouse III, Toulouse, France.
Arnaud ConstantinCentre de rhumatologie, CHU de Toulouse, UMR 1043, CPTP, Inserm, Université Paul Sabatier Toulouse III, Toulouse, France.
Université Toulouse III - Paul Sabatier · FRCentre Hospitalier Universitaire de Toulouse · FRUniversité Paris-Est Créteil · FR

Funding

société française de rhumatologie NA
6 · The paper itself

Abstract

backgroundTo investigate the association between 12 single nucleotide polymorphisms (SNPs) located on ERAP1 and IL23R with the presence of inflammation on the sacroiliac joint (SIJ) or spinal magnetic resonance imagery (MRI) in an early onset spondyloarthritis (SpA) cohort.

methodsAll the patients included in the DESIR cohort with an axial SpA and available DNA at baseline were enrolled in this study (n = 645 patients) and underwent a clinical examination, CRP assay, SIJ and spinal MRI scans. Six SNPs located on ERAP1 (rs30187, rs27044, rs27434, rs17482078, rs10050860, rs2287987) and six SNPs located on IL23R (rs1004819, rs10489629, rs1343151, rs2201841, rs10889677, rs11209032) were genotyped. Univariable analyses were performed to test the association between the genotypes and SIJ and spinal MRI inflammation, as well as disease activity based on Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Disease Activity Score-C-Reactive Protein (ASDAS-CRP) and CRP.

resultsOne SNP located on ERAP1 (rs27434) and haplotype CCT of ERAP1 were associated with SIJ inflammation detected by MRI, but these associations were below the Bonferroni corrected threshold of significance. However, one SNP (rs1004819) located on IL23R was associated with SIJ MRI inflammation (rs1004819: TT 42.3%, CT 40.5%, CC 26.5%, p = 0.0005). This locus was also significantly associated with Spondyloarthritis Research Consortium of Canada scores while no association with another inflammatory parameter such as BASDAI, ASDAS-CRP, CRP or Berlin MRI score was identified in this population.

conclusionOne locus of the IL23R gene was associated with SIJ MRI inflammation and might be a marker of more active disease in recent onset SpA.

trial registrationclinicaltrials.gov, NCTO 164 8907.

Indexed as

AdultAminopeptidasesCohort StudiesFemaleGenetic Association StudiesHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMinor Histocompatibility AntigensPolymorphism, Single NucleotideProspective StudiesReceptors, InterleukinSacroiliac JointSpineSpondylarthritisAminopeptidasesERAP1 protein, humanIL23R protein, humanMinor Histocompatibility AntigensReceptors, InterleukinPolymorphismsSacroiliitisSpondyloarthritis

Identifiers

PMID30646942
PMCPMC6332609
OpenAlexW2921260082

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.