ReviewDiagnostic pathology2019
Mediastinal follicular dendritic cell sarcoma: a rare, potentially under-recognized, and often misdiagnosed disease.
Review in Diagnostic pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Pancreatic follicular dendritic cell sarcoma: a rare case report and systematic literature review of 7 cases.World journal of surgical oncology · 2023Pooled it
- Clinicopathological characteristics of intra-abdominal follicular dendritic cell sarcomas: A multicenter real-world study.iScience · 2026Article
- Description of two cases of follicular dendritic cell sarcoma, including next-generation sequencing analysis.Diagnostic pathology · 2025Article
- Case Report: A middle-aged woman with mediastinal follicular dendritic cell sarcoma complicated by paraneoplastic pemphigus.Frontiers in oncology · 2025Article
- Rare co-occurrence of tonsillar follicular dendritic cell sarcoma and schizophrenia: A comprehensive study.Clinical case reports · 2024Article
- Angioimmunoblastic T-Cell Lymphoma with Exuberant CD30-Positive Follicular Dendritic Cell Proliferation in a SARS-CoV-2 Patient: The Role of Mutational Analysis to Exclude an Associated Follicular Dendritic Cell Sarcoma.International journal of molecular sciences · 2022Article
- Promising clinical outcome after body gamma knife radiotherapy for mediastinal follicular dendritic cell sarcoma with thoracic spine invasion and iliac metastasis: A case report and literature review.Frontiers in oncology · 2022Article
- Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases.Oncology letters · 2021Article
- Mediastinal soft tissue sarcoma: dark sides and future lights.Mediastinum (Hong Kong, China) · 2020Article
- Follicular Dendritic Cell Sarcoma With Co-Expression of CD4 and CD30 Mimics Anaplastic Large Cell Lymphoma.Frontiers in oncology · 2020Article
- Nodal follicular dendritic cell sarcoma with four atypical histomorphologic features: an unusual case report.Diagnostic pathology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMediastinal follicular dendritic cell sarcoma (FDCS) is extremely rare. Due to potential under-recognization of this disease, it happens to be misdiagnosed, especially on core needle biopsy. We report 3 cases of mediastinal FDCS and provide a literature review to improve better understanding of the tumor and to reduce misdiagnosis.
methodsThree cases of mediastinal FDCS in our clinic practice were studied, including their core needle biopsy and resected specimens, and those cases reported previously in English literature were retrieved and analyzed.
resultsThe core needle biopsy of case 1 showed a tumor reminiscent of classical Hodgkin's lymphoma (CHL), while the resected mass was finally diagnosed with FDCS combined with hyaline-vascular Castleman's disease. Both the biopsy and resected tissue of case 2 were constitutive of the clear epithelioid cells with marked atypia. In both cases, definitive diagnoses were not made on core needle biopsy. In case 3, there were some areas morphologically similar to CHL, and some areas contained ovoid to spindle-shaped tumor cells with fascicular pattern. The analysis of 43 cases of mediastinal FDCS showed the age of patients were from 16 to 76 years old, the male to female ratio was 1.5:1, the maximal tumor diameters were 3-17 cm. 18 cases were underwent preoperative biopsy, whereas 15 (83.3%) of which were misdiagnosed initially, often as lymphoma. 32 patients had available follow-up data, the rates of recurrence, metastasis, and mortality were 12.5, 18.8 and 28.1%, respectively. Current limited data suggested no statistical differences between adverse prognosis and gender, age, tumor size, necrosis, or different therapeutics, respectively.
conclusionsMediastinal FDCS is a rare malignancy that has yet not been fully understood and been often misdiagnosed, particularly when making a diagnosis on core needle biopsy. Increased awareness of this enigmatic tumor is crucial to avoid diagnostic pitfalls.
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