Evidence map›Paper›PMID 30646920›Full record

ReviewJournal of biomedical science2019

Toward characterizing extracellular vesicles at a single-particle level.

Chun-Yi Chiang, Chihchen Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of biomedical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chun-Yi ChiangInstitute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu, 30013, Taiwan.
Chihchen ChenInstitute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu, 30013, Taiwan. chihchen@mx.nthu.edu.tw.ORCID http://orcid.org/0000-0002-2195-4802

Funding

Ministry of Science and Technology, Taiwan 106-2221-E-007-003Ministry of Science and Technology, Taiwan 106-2628-E-007-010-MY3
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are cell-derived membrane-bound vesicles that serve a means of cell-cell communication. Studying EVs at a single-particle level is important because EVs are inherently heterogeneous. Novel micro- and nanotechnological tools have open opportunities for realizing single-EV measurements exploiting their biochemical, electrical, mechanical, and/or optical properties. This review summarizes the recent development of technologies toward sorting and analyzing single EVs. Sorting EVs into a more homogeneous subset relaxes the sensitivity and throughput required on the EV detection, and hence related techniques are also included in this review. These exciting technologies are on the rise and will expand our understanding of EVs and their applications in the near future.

Indexed as

AnimalsEnzyme-Linked Immunosorbent AssayExtracellular VesiclesFlow CytometryHumansMicroscopyPolymerase Chain ReactionSpectrum Analysis, RamanAtomic force microscopyDigital PCRElectrophoresisExosomeExtracellular vesicleMicrovesicleRaman spectroscopySingle particle

Identifiers

PMID30646920
PMCPMC6332877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.