Trial reportBMC psychiatry2019
A randomized controlled trial of cognitive remediation for a national cohort of forensic patients with schizophrenia or schizoaffective disorder.
Trial report in BMC psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02360813 (Randomised Controlled Trial to Evaluate the Efficacy of Cognitive Remediation Within a Secure Forensic Setting for Schizophrenia Spectrum Patients), which is not on this map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomised Controlled Trial to Evaluate the Efficacy of Cognitive Remediation Within a Secure Forensic Setting for Schizophrenia Spectrum Patients
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Cognitive behavioural therapy plus standard care versus standard care for persistent aggressive behaviour or agitation in people with schizophrenia.The Cochrane database of systematic reviews · 2023Pooled it
- Factors Impacting Access and Engagement of Cognitive Remediation Therapy for People with Schizophrenia: A Systematic Review.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2023Pooled it
- Effectiveness, Core Elements, and Moderators of Response of Cognitive Remediation for Schizophrenia: A Systematic Review and Meta-analysis of Randomized Clinical Trials.JAMA psychiatry · 2021Pooled it
- Understanding the Mechanisms of Cognitive Remediation on Recovery in People With Early Psychosis: A Mediation and Moderation Analysis.Schizophrenia bulletin · 2024Trial
- Examining the impact of a group treatment using cognitive and social cognition remediation for young offenders: The justice health NSW school-link advantage pilot study.Early intervention in psychiatry · 2025Article
- Thinking About the Future of Cognitive Remediation Therapy Revisited: What Is Left to Solve Before Patients Have Access?Schizophrenia bulletin · 2024Article
- Service User Representation in Qualitative Research on Cognitive Health and Related Interventions for Psychosis: A Scoping Review.Schizophrenia bulletin · 2024Article
- Cognitive function characteristics and influencing factors in patients with depressive disorders: a 5-year follow-up report based on the epidemiological survey of mental disorders in Shandong Province, China.Frontiers in psychiatry · 2024Article
- Cognitive and clinical characteristics of offenders and non-offenders diagnosed with schizophrenia spectrum disorders: results of the Recoviwel observational study.European archives of psychiatry and clinical neuroscience · 2023Observational
- Plasma neurofilament light chain protein is not increased in forensic psychiatric populations: a pilot study.Frontiers in psychiatry · 2023Article
- Article
- Cognitive Remediation in Psychiatric Disorders: State of the Evidence, Future Perspectives, and Some Bold Ideas.Brain sciences · 2022Review
- General description of cognitive deficits in schizophrenia and assessment tools in Lebanon: A scoping review.Schizophrenia research. Cognition · 2021Article
- Forensic psychiatry and Covid-19: accelerating transformation in forensic psychiatry.Irish journal of psychological medicine · 2021Article
- Cognitive Remediation for Schizophrenia.Focus (American Psychiatric Publishing) · 2020Article
- Trait Disinhibition and NoGo Event-Related Potentials in Violent Mentally Disordered Offenders and Healthy Controls.Frontiers in psychiatry · 2020Article
- Cognitive remediation for severe mental illness: state of the field and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2019Article
- Focus on Brain Health to Improve Care, Treatment, and Rehabilitation in Forensic Psychiatry.Frontiers in psychiatry · 2019Article
- Perspective On Excellence in Forensic Mental Health Services: What We Can Learn From Oncology and Other Medical Services.Frontiers in psychiatry · 2019Article
- Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain.Frontiers in cellular neuroscience · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence is accumulating that Cognitive Remediation Training (CRT) is effective for ameliorating cognitive deficits experienced by patients with schizophrenia and accompanying functional impairment. There has been no randomized controlled trial of CRT using a nationally representative population of forensic patients, despite the significant cognitive deficits frequently present within this group.
methodsSixty-five patients with schizophrenia or schizoaffective disorder were enrolled in a single blind randomized controlled trial of CRT versus treatment as usual (TAU); representing 94% of those eligible within a national forensic cohort. The primary outcome measure was the composite score of the MATRICS Consensus Cognitive Battery (MCCB). Secondary outcome measures included neurocognitive and social cognitive domains, symptoms, and 'real world' functioning. Patient satisfaction was examined using an exit interview. Participants were reassessed at 8 months follow up. All data were analyzed using an intention to treat design (ITT).
resultsFor the primary outcome measure, the MCCB composite score, there were significant differences between those who participated in CRT and those receiving TAU at both end of treatment and 8 months follow up (Cohen's d = 0.34. Significant improvements were observed in visual and working memory. Mediation analysis found that those who cognitively benefited from CRT had corresponding improved functioning, and more net positive therapeutic moves i.e. moves to units with lower security within the hospital. Ninety-six percent believed their cognitive gains positively affected their daily lives.
conclusionsCRT may be an acceptable and efficacious intervention for forensic patients with schizophrenia or schizoaffective disorder.
trial registrationClinicalTrials.gov Identifier: NCT02360813 . Trial registered Feb 4th 2015, last updated May 1st 2015.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.