Evidence map›Paper›PMID 30646867›Full record

ArticleBMC public health2019

Rotavirus gastroenteritis in Indian children < 5 years hospitalized for diarrhoea, 2012 to 2016.

Sidhartha Giri, Nayana P Nair, Ann Mathew, B Manohar, Anna Simon, Tejinder Singh, S Suresh Kumar, M A Mathew, Sudhir Babji, Rashmi Arora and 5 more

Abstract read
In one paragraph

Article in BMC public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Frontiers in microbiology · 2026
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  7. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sidhartha GiriDivision of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
Nayana P NairDivision of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
Ann MathewDepartment of Paediatrics, St. Stephen's Hospital, Tis Hazari, New Delhi, India.
B ManoharDepartment of Paediatrics, SV Medical College, Tirupati, Andhra Pradesh, India.
Anna SimonDepartment of Paediatrics, Christian Medical College, Vellore, Tamil Nadu, India.
Tejinder SinghDepartment of Paediatrics, Christian Medical College, Ludhiana, Punjab, India.
S Suresh KumarPunjagutta, Pragna Hospital, Hyderabad, Telangana, India.
M A MathewDepartment of Paediatrics, Malankara Orthodox Syrian Church Medical College, Kolenchery, Kerala, India.
Sudhir BabjiDivision of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
Rashmi AroraIndian Council of Medical Research, New Delhi, India.
C P Girish KumarNational Institute of Epidemiology, Chennai, Tamil Nadu, India.
S VenkatasubramanianNational Institute of Epidemiology, Chennai, Tamil Nadu, India.
Sanjay MehendaleIndian Council of Medical Research, New Delhi, India.
Mohan D GupteIndian Council of Medical Research, New Delhi, India.
Gagandeep KangDivision of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India. gkang@cmcvellore.ac.in.ORCID http://orcid.org/0000-0002-3656-564X

Funding

Multi-disciplinary research training in enteric infectionsD43TW007392 · FIC · CHRISTIAN MEDICAL COLLEGE · PI KANG, GAGANDEEP · 2005 to 2020
$2.9M
GENETIC ANALYSIS OF HUMAN LYMPHOID NEOPLASIAK04CA001189 · NCI · STANFORD UNIVERSITY · PI SKLAR, JEFFREY · 1987 to 1991
–
Bill and Melinda Gates Foundation OPP1053989FIC NIH HHS D43 TW007392Indian Council of Medical Research 5/8-1(189)/TF/2011-12-ECD
6 · The paper itself

Abstract

backgroundIn 2016, the Government of India introduced the oral rotavirus vaccine (ROTAVAC, Bharat Biotech, India) in 4 states of India as part of the Universal Immunization Programme, and expanded to 5 more states in 2017. We report four years of data on rotavirus gastroenteritis in hospitalized children < 5 years of age prior to vaccine introduction.

methodsChildren from 7 sites in southern and northern India hospitalized for diarrhoea were recruited between July 2012 and June 2016. Stool samples were screened for rotavirus using enzyme immunoassay (EIA). The EIA positive samples were genotyped by reverse-transcription polymerase chain reaction.

resultsOf the 5834 samples from the 7 sites, 2069 (35.5%) were positive for rotavirus by EIA. Genotyping was performed for 2010 (97.1%) samples. G1P[8](56.3%), G2P[4](9.1%), G9P[4](7.6%), G9P[8](4.2%), and G12P[6](3.7%) were the common genotypes in southern India and G1P[8](36%), G9P[4](11.4%), G2P[4](11.2%), G12P[6](8.4%), and G3P[8](5.9%) in northern India.

conclusionsThe study highlights the high prevalence of rotavirus gastroenteritis in India and the diversity of rotavirus genotypes across different geographical regions. Pre- vaccine surveillance data is necessary to evaluate the potential change in admission rates for gastroenteritis and circulating rotavirus genotypes after vaccine introduction, thus assessing impact.

Indexed as

GenotypeRotavirus VaccinesChild, PreschoolDiarrheaEnterovirus InfectionsFecesFemaleGastroenteritisHospitalizationHumansImmunization ProgramsIndiaInfantMalePrevalenceResidence CharacteristicsRotavirus VaccinesDiarrhoeaEnzyme immunoassayGastroenteritisGenotypesIndiaPolymerase chain reactionRotavirus

Identifiers

PMID30646867
PMCPMC6334384

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.