ArticleCirculation research2019
Type 2 Diabetes and Hypertension.
Article in Circulation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 7 of them syntheses that pooled it.
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The trial behind it
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Who cites it
133 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Effect of tirzepatide and semaglutide on blood pressure: A systematic review and meta-analysis.Endocrine · 2026Pooled it
- [Individualizing antihypertensive therapy in diabetes mellitus. Guidelines of the Austrian Diabetes Association (Update 2026)].Wiener klinische Wochenschrift · 2026Guideline
- Semaglutide reduces cardiovascular events in type 2 diabetes: a systematic review and meta-analysis highlighting enhanced benefits in chronic kidney disease.European journal of medical research · 2025 · on this mapPooled it
- Hypertension in Adults With Diabetes in Southeast Asia: A Systematic Review.Journal of clinical hypertension (Greenwich, Conn.) · 2025Pooled it
- Pharmacological Nephroprotection in Chronic Kidney Disease Patients with Type 2 Diabetes Mellitus-Clinical Practice Position Statement of the Polish Society of Nephrology.International journal of molecular sciences · 2024Guideline
- [Individualising antihypertensive therapy in patients with diabetes. A guideline by the Austrian Diabetes Association (update 2023)].Wiener klinische Wochenschrift · 2023Guideline
- Smoking and heart failure: a Mendelian randomization and mediation analysis.ESC heart failure · 2021Pooled it
- Effects of an Iranian traditional fermented food consumption on blood glucose, blood pressure, and lipid profile in type 2 diabetes: a randomized controlled clinical trial.European journal of nutrition · 2022Trial
- Antihypertensive medication needs and blood pressure control with weight loss in the Diabetes Remission Clinical Trial (DiRECT).Diabetologia · 2021Trial
- The effect of glucagon-like peptide-1 receptor agonists liraglutide and semaglutide on cardiovascular and renal outcomes across baseline blood pressure categories: Analysis of the LEADER and SUSTAIN 6 trials.Diabetes, obesity & metabolism · 2020 · on this mapTrial
- Association of hypertension specialist treatment with blood pressure control in Japanese primary care: The J-DOME study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Resistant Hypertension Variants Link to Hyperaldosteronism and Potassium Levels.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Article
- The effect of medication use on chronic pruritus in patients with type 2 diabetes mellitus: a multicenter cross-sectional study.Scientific reports · 2026Article
- Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity.Nature communications · 2026Article
- The dominant driver paradigm of cardiometabolic care.American journal of preventive cardiology · 2026Article
- Prevalence of diabetes/prediabetes and their associated risk factors among adults with hypertension from iran: a nationwide study.Scientific reports · 2026Article
- Association between mental health service utilization and diabetes-hypertension comorbidity: a community-based study.Frontiers in public health · 2026Article
- Application of machine learning approaches to develop predictive models for diabetes and hypertension among Bangladeshi Adults.PLOS global public health · 2026Article
- Prevalence and Factors Associated With Hypertension Among Type 2 Diabetic Patients in Private Health Facilities, Kampala, Uganda.International journal of hypertension · 2026Article
73 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
rationaleIn observational studies, type 2 diabetes mellitus (T2D) has been associated with an increased risk of hypertension, and vice versa; however, the causality between these conditions remains to be determined.
objectivesThis population-based prospective cohort study sought to investigate the bidirectional causal relations of T2D with hypertension, systolic and diastolic blood pressure (BP) using Mendelian randomization (MR) analysis. METHODS AND
resultsAfter exclusion of participants free of a history of heart failure, cardiovascular disease, cardiac procedures, and non-T2D diabetes mellitus, a total of 318 664 unrelated individuals with qualified genotyping data of European descent aged 37 to 73 from UK Biobank were included. The genetically instrumented T2D and hypertension were constructed using 134 and 233 single nucleotide polymorphisms, respectively. Seven complementary MR methods were applied, including inverse-variance weighted method, 2 median-based methods (simple and weighted), MR-Egger, MR-robust adjusted profile scores, MR-Pleiotropy Residual Sum and Outlier, and multivariate MR. The genetically instrumented T2D was associated with risk of hypertension (odds ratio, 1.07 [95% CI, 1.04-1.10], P=3.4×10
conclusionsT2D may causally affect hypertension, whereas the relationship from hypertension to T2D is unlikely to be causal. These findings suggest the importance of keeping an optimal glycemic profile in general populations, and BP screening and monitoring, especially systolic BP, in patients with T2D.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.