Evidence map›Paper›PMID 30646812›Full record

ArticleCell cycle (Georgetown, Tex.)2019

miR-506 contributes to malignancy of cutaneous squamous cell carcinoma via targeting of P65 and LAMC1.

Jian Zhou, Ying Zhang, Zhaofeng Han, Zhiwei Dong, Tongtong Cao, Aizhou Wei, Pengfei Guo, Qingnan Meng

RetractedOpen access · bronzeAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Oh, the Mutations You'll Acquire! A Systematic Overview of Cutaneous Squamous Cell Carcinoma.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2021
    Review
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jian Zhoua Department of Burn and Reconstruction , the First Affliated Hospital of Zhengzhou University , Zhengzhou , China.
Ying Zhangb Department of Endocrinology and Metabolism , the First Affliated Hospital of Zhengzhou University , Zhengzhou , China.
Zhaofeng Hana Department of Burn and Reconstruction , the First Affliated Hospital of Zhengzhou University , Zhengzhou , China.
Zhiwei Dongc Department of General Surgery , the Air Force General Hospital PLA , Beijing , China.
Tongtong Caod Department of Traditional Chinese Medicine , Beijing Children's Hospital, Capital Medical University, National Center for Children's Health , Beijing , China.
Aizhou Weia Department of Burn and Reconstruction , the First Affliated Hospital of Zhengzhou University , Zhengzhou , China.
Pengfei Guoa Department of Burn and Reconstruction , the First Affliated Hospital of Zhengzhou University , Zhengzhou , China.
Qingnan Menga Department of Burn and Reconstruction , the First Affliated Hospital of Zhengzhou University , Zhengzhou , China.
First Affiliated Hospital of Zhengzhou University · CNAir Force General Hospital PLA · CNBeijing Children’s Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous research has shown that microRNA 506 (miR-506) functions as an essential modulator in the development of many biological reactions, including multiple cancers. However, its involvement in cutaneous squamous cell carcinoma (CSCC) has been rarely reported. In the present work, we investigated the molecular mechanism and function of miR-506 in the regulation of CSCC cell viability and metastasis (migration and invasion). We observed that miR-506 expression was upregulated in both CSCC tissues and cell lines, and that decreased miR-506 expression led to repressed tumorigenesis in CSCC cells. Furthermore, flow cytometry revealed that the depletion of miR-506 resulted in decreased proliferation and increased apoptotic levels in CSCC cells. Meanwhile, it was found that miR-506 decreased CSCC cell migration and invasion in vitro. The dual-luciferase reporter assay also revealed that miR-506 targets the 3'-UTRs of p65 and Laminin C1 (LAMC1) for silencing. Silencing of p65 expression counteracted the pro-apoptotic influence of miR-506 depletion in CSCC cells, while inhibition of LAMC1 expression restored the migration and invasion properties of the CSCC cells. Therefore, the results provide evidence for the need to probe the biological and molecular mechanisms behind the development and progression of CSCC and may lead to novel treatment CSCC strategies.

Indexed as

3' Untranslated RegionsAnimalsApoptosisCarcinogenesisCarcinoma, Squamous CellCell Line, TumorCell MovementCell ProliferationGene SilencingHumansLamininMice, Inbred BALB CMicroRNAsNeoplasm InvasivenessSkin NeoplasmsTranscription Factor RelA3' Untranslated RegionsLamininlaminin gamma 1MicroRNAsMIRN506 microRNA, humanTranscription Factor RelAapoptosiscutaneous squamous cell carcinomaLAMC1metastasisMiR-506p65

Identifiers

PMID30646812
PMCPMC6380411
OpenAlexW2908697086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.