Evidence map›Paper›PMID 30646542›Full record

ArticleToxins2019

Intradermal Application of Crotamine Induces Inflammatory and Immunological Changes In Vivo.

Ana Vitória Pupo Silvestrini, Luana Henrique de Macedo, Thiago Antônio Moretti de Andrade, Maíra Felonato Mendes, Acácio Antônio Pigoso, Maurício Ventura Mazzi

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Effects of venoms on neutrophil respiratory burst: a major inflammatory function.The journal of venomous animals and toxins including tropical diseases · 2021
    Review
  7. Article
  8. Experimental models and methods for cutaneous wound healing assessment.International journal of experimental pathology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ana Vitória Pupo SilvestriniSchool of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, CEP 14040-903 Ribeirão Preto, SP, Brazil. anapupo@usp.br.
Luana Henrique de MacedoSchool of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, CEP 14040-903 Ribeirão Preto, SP, Brazil. luana.hdm@usp.br.
Thiago Antônio Moretti de AndradeGraduate Program in Biomedical Sciences Hermínio Ometto University Center, FHO-UNIARARAS, Av. Dr. Maximiliano Baruto, 500, CEP 13607-339 Araras, SP, Brazil. thiago.andrade@fho.edu.br.ORCID 0000-0003-3788-2847
Maíra Felonato MendesGraduate Program in Biomedical Sciences Hermínio Ometto University Center, FHO-UNIARARAS, Av. Dr. Maximiliano Baruto, 500, CEP 13607-339 Araras, SP, Brazil. mairafelonato@fho.edu.br.
Acácio Antônio PigosoGraduate Program in Biomedical Sciences Hermínio Ometto University Center, FHO-UNIARARAS, Av. Dr. Maximiliano Baruto, 500, CEP 13607-339 Araras, SP, Brazil. acaciopigoso@uniararas.br.
Maurício Ventura MazziGraduate Program in Biomedical Sciences Hermínio Ometto University Center, FHO-UNIARARAS, Av. Dr. Maximiliano Baruto, 500, CEP 13607-339 Araras, SP, Brazil. maumazzi@fho.edu.br.
Centro Universitário Herminio Ometto de Araras · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crotamine is a single-chain polypeptide with cell-penetrating properties, which is considered a promising molecule for clinical use. Nevertheless, its biosafety data are still scarce. Herein, we assessed the in vivo proinflammatory properties of crotamine, including its local effect and systemic serum parameters. Sixty male

Indexed as

AnimalsC-Reactive ProteinCrotalid VenomsInflammationInjections, IntradermalInterleukin-10MaleNeovascularization, PhysiologicNitric OxideRats, WistarTumor Necrosis Factor-alphaC-Reactive ProteinCrotalid VenomscrotamineInterleukin-10Nitric OxideTumor Necrosis Factor-alphacell-penetrating peptideCrotalus durissus terrificuscrotamineinflammation

Identifiers

PMID30646542
PMCPMC6357061
OpenAlexW2910155122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.