Evidence map›Paper›PMID 30646534›Full record

ArticlePharmaceutics2019

Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles.

Diana Díaz-García, Perla R Ardiles, Sanjiv Prashar, Antonio Rodríguez-Diéguez, Paulina L Páez, Santiago Gómez-Ruiz

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 62 citations in OpenAlex.

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  6. Organically Modified Mesoporous Silica Nanoparticles against Bacterial Resistance.Chemistry of materials : a publication of the American Chemical Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Diana Díaz-GarcíaDepartamento de Biología y Geología, Física y Química Inorgánica, ESCET, Universidad Rey Juan Carlos, Calle Tulipán s/n, E-28933 Móstoles (Madrid), Spain. diana.diaz@urjc.es.
Perla R ArdilesDepartamento de Ciencias Farmacéuticas. Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. Ciudad Universitaria, Haya de la Torre y Medina Allende, X5000HUA Córdoba, Argentina. pardiles@fcq.unc.edu.ar.
Sanjiv PrasharDepartamento de Biología y Geología, Física y Química Inorgánica, ESCET, Universidad Rey Juan Carlos, Calle Tulipán s/n, E-28933 Móstoles (Madrid), Spain. sanjiv.prashar@urjc.es.ORCID 0000-0002-6588-878X
Antonio Rodríguez-DiéguezDepartamento de Química Inorgánica, Universidad de Granada, Facultad de Ciencias, Campus de Fuentenueva, Avda. Fuentenueva s/n, E-18071 Granada, Spain. antonio5@ugr.es.ORCID 0000-0003-3198-5378
Paulina L PáezDepartamento de Ciencias Farmacéuticas. Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. Ciudad Universitaria, Haya de la Torre y Medina Allende, X5000HUA Córdoba, Argentina. plpaez@fcq.unc.edu.ar.
Santiago Gómez-RuizDepartamento de Biología y Geología, Física y Química Inorgánica, ESCET, Universidad Rey Juan Carlos, Calle Tulipán s/n, E-28933 Móstoles (Madrid), Spain. santiago.gomez@urjc.es.ORCID 0000-0001-9538-8359
Universidad Rey Juan Carlos · ESUniversidad Nacional de Córdoba · ARUniversidad de Granada · ES

Funding

Agencia Nacional de Promoción Científica y Tecnológica PICT 2015 N° 1558Ministerio de Ciencia e Innovación CTQ2015-66164-RMinisterio de Ciencia e Innovación CTQ2017-90802-REDT
6 · The paper itself

Abstract

Mesoporous silica nanoparticles (MSNs) are an interesting class of nanomaterials with potential applications in different therapeutic areas and that have been extensively used as drug carriers in different fields of medicine. The present work is focused on the synthesis of MSNs containing a maleamato ligand (MSN-maleamic) and the subsequent coordination of copper(II) ions (MSN-maleamic-Cu) for the exploration of their potential application as antibacterial agents. The Cu-containing nanomaterials have been characterized by different techniques and the preliminary antibacterial effect of the supported maleamato-copper(II) complexes has been tested against two types of bacteria (Gram positive and Gram negative) in different assays to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The biological results showed a moderate antibacterial activity against

Indexed as

antibacterialcoppermaleamatesmesoporous silica nanoparticlesoxidation reactionsROS

Identifiers

PMID30646534
PMCPMC6359009
OpenAlexW2909145399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.