Evidence map›Paper›PMID 30646484›Full record

ArticleJournal of neurogastroenterology and motility2019

Pelvic Floor Symptom Related Distress in Chronic Constipation Correlates With a Diagnosis of Irritable Bowel Syndrome With Constipation and Constipation Severity but Not Pelvic Floor Dyssynergia.

Prashant Singh, Yoonjin Seo, Sarah Ballou, Andrew Ludwig, William Hirsch, Vikram Rangan, Johanna Iturrino, Anthony Lembo, Judy W Nee

Open access · diamondAbstract read
In one paragraph

Article in Journal of neurogastroenterology and motility, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Factors Associated With the Severity of Chronic Constipation Among Japanese University Students.JGH open : an open access journal of gastroenterology and hepatology · 2025
    Article
  2. Review
  3. Article
  4. Raising the Bar in the Management of IBS-C.Gastroenterology & hepatology · 2023
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Prashant SinghDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, USA.
Yoonjin SeoDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, USA.
Sarah BallouDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, USA.
Andrew LudwigDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, USA.
William HirschDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, USA.
Vikram RanganDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, USA.
Johanna IturrinoDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, USA.
Anthony LemboDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, USA.
Judy W NeeDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, USA.
Beth Israel Deaconess Medical Center · US

Funding

RESEARCH TRAINING IN GASTROENTEROLOGYT32DK007760 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KELLY, CIARAN P · 1999 to 2019
$4.6M
Efficacy of Open-Label Placebo, Double-Blind Placebo, and Peppermint Oil in IBSR01AT008573 · NCCIH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAPTCHUK, TED, LEMBO, ANTHONY J · 2015 to 2019
$4.3M
NCCIH NIH HHS R01 AT008573NIDDK NIH HHS T32 DK007760
6 · The paper itself

Abstract

BACKGROUND/

aimsAlthough symptoms related to the pelvic floor, such as pelvic organ prolapse (POP) and lower urinary tract symptoms (LUTS), are common in patients with chronic constipation (CC), its impact is not clear. Our aims were to investigate the following (1) compare pelvic floor symptom related dysfunction in irritable bowel syndrome with constipation (IBS-C) and functional constipation (FC), and (2) symptom correlation with findings on anorectal manometry (ARM) and balloon expulsion test.

methodsThis was a retrospective analysis of patients with CC undergoing ARM. IBS-C and FC were diagnosed by Rome III criteria. Pelvic Floor Distress Inventory (PFDI-20) was used to measure pelvic floor symptom distress. Constipation Severity Scale was used to assess constipation severity.

resultsA total of 107 patients underwent ARM (64 FC, 43 IBS-C). The overall PFDI-20 score in IBS-C was higher compared with FC patients (118.0 vs 79.2,

conclusionsCompared with FC patients, those with IBS-C have significantly higher distress from pelvic floor specific symptoms including POP and LUTS. Higher abdominal pain among IBS-C patients did not entirely explain these findings. A diagnosis of IBS-C and higher constipation severity correlated with PFDI-20 scores, but dyssynergia did not.

Indexed as

ConstipationDefecationLower urinary tract symptomsManometryPelvic floor

Identifiers

PMID30646484
PMCPMC6326213
OpenAlexW2910229649

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.