ReviewRevista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia2019
Isthmocele: From Risk Factors to Management.
Review in Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04579965 (Misotac vs Combined Oral Contraceptive Pill in the Treatment of Symptomatic Isthmocele), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Misotac vs Combined Oral Contraceptive Pill in the Treatment of Symptomatic Isthmocele
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- High live birth rates after laparoscopic isthmocele repair in infertility: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Impact of obstetric and surgical factors on isthmocele development: insights from a prospective cohort study.Archives of gynecology and obstetrics · 2026Article
- Isthmocele risk in repeated cesarean: the diagnostic and clinical role of morphometric parameters.Archives of gynecology and obstetrics · 2025Article
- Development of the Er-Kay Classification: A Novel Volume-Based Assessment of Cesarean Scar Defects and Their Association with Abnormal Uterine Bleeding.Journal of clinical medicine · 2025Article
- Article
- Isthmocele‑an iatrogenic pathology: A prospective study in a tertiary unit.Biomedical reports · 2025Article
- Analysis of outcomes of laparotomic, laparoscopic, and hysteroscopic symptomatic ısthmocele (niche) repair in Turkish women.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Article
- Investigating the risk factors for isthmocele development after cesarean delivery.AJOG global reports · 2024Article
- Isthmocele and Infertility.Journal of clinical medicine · 2024Review
- Instrumental Diagnosis of Placenta Accreta and Obstetric and Perinatal Outcomes: Literature Review and Observational Study.Translational medicine @ UniSa · 2024Article
- Efficacy, Safety and Outcomes of the Laparoscopic Management of Cesarean Scar Ectopic Pregnancy as a Single Therapeutic Approach: A Case Series.Journal of clinical medicine · 2023Article
- Comparison of classic single-layer uterin suture and double-layer purse-string suture techniques for uterus closure in terms of postoperative short-term uterine isthmocele: A prospective randomized controlled trial.Turkish journal of obstetrics and gynecology · 2023Article
- Mucinous Cystadenoma Arising in a Uterine Isthmocele: A Case Report.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2023Article
- Impact of Adenomyosis and Endometriosis on Chronic Pelvic Pain after Niche Repair.Journal of clinical medicine · 2023Article
- Postoperative morphologic changes of the isthmocele and clinical impact in patients treated by channel-like (360°) hysteroscopic technique.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2023Article
- Post-caesarean Niche (Isthmocele) in Uterine Scar: An Update.Journal of obstetrics and gynaecology of India · 2020Review
- Prevalence, definition, and etiology of cesarean scar defect and treatment of cesarean scar disorder: A narrative review.Reproductive medicine and biologyReview
- Association Between Hysteroscopic Treatment of Cesarean Scar Disorder and Changes in the Endometrial Microbiome and Clinical Outcomes: A Prospective Observational Study.Reproductive medicine and biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of the present study was to perform a comprehensive review of the literature to provide a complete and clear picture of isthmocele-a hypoechoic area within the myometrium at the site of the uterine scar of a previous cesarean section-by exploring in depth every aspect of this condition.
methodsA comprehensive review of the literature was performed to identify the most relevant studies about this topic.
resultsEvery aspect of isthmocele has been studied and described: pathophysiology, clinical symptoms, classification, and diagnosis. Its treatment, both medical and surgical, has also been reported according to the actual literature data.
conclusionCesarean section is the most common surgical procedure performed worldwide, and one of the consequences of this technique is isthmocele. A single and systematic classification of isthmocele is needed to improve its diagnosis and management. Further studies should be performed to better understand its pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.