ArticleJAMA network open2018
Evaluation of Differences in Temporal Synchrony Between Brain Regions in Individuals With Autism and Typical Development.
Article in JAMA network open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Serotonin differentially modulates the temporal dynamics of the limbic response to facial emotions in male adults with and without autism spectrum disorder (ASD): a randomised placebo-controlled single-dose crossover trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- A generalized scaling law reveals synchrony-driven reorganization of brain dynamics across human lifespan.PLoS computational biology · 2026Article
- Reduced lateralization of multiple functional brain networks in autistic males.Journal of neurodevelopmental disorders · 2024Article
- Reduced Lateralization of Multiple Functional Brain Networks in Autistic Males.bioRxiv : the preprint server for biology · 2023Article
- Longitudinal Stability of Intellectual Functioning in Autism Spectrum Disorder: From Age 3 Through Mid-adulthood.Journal of autism and developmental disorders · 2022Article
- Blood Oxygen Level-Dependent Lag Patterns Differ Between Rest and Task Conditions, but Are Largely Typical in Autism.Brain connectivity · 2022Article
- Reconfiguration of Brain Network Dynamics in Autism Spectrum Disorder Based on Hidden Markov Model.Frontiers in human neuroscience · 2022Article
- Attentive brain states in infants with and without later autism.Translational psychiatry · 2021Article
- Brain and motor synchrony in children and adolescents with ASD-a fNIRS hyperscanning study.Social cognitive and affective neuroscience · 2021Article
- Time-delay structure predicts clinical scores for patients with disorders of consciousness using resting-state fMRI.NeuroImage. Clinical · 2021Article
- Multi-scale network regression for brain-phenotype associations.Human brain mapping · 2020Article
- Does higher sampling rate (multiband + SENSE) improve group statistics - An example from social neuroscience block design at 3T.NeuroImage · 2020Article
- Nonreplication of functional connectivity differences in autism spectrum disorder across multiple sites and denoising strategies.Human brain mapping · 2020Article
- Dynamic lag analysis reveals atypical brain information flow in autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2020Article
- Beyond diagnosis: Cross-diagnostic features in canonical resting-state networks in children with neurodevelopmental disorders.NeuroImage. Clinical · 2020Article
- Children With Autism Produce a Unique Pattern of EEG Microstates During an Eyes Closed Resting-State Condition.Frontiers in human neuroscience · 2020Article
- Beery VMI and Brain Volumetric Relations in Autism Spectrum Disorder.Journal of pediatric neuropsychology · 2019Article
- Generalizability and reproducibility of functional connectivity in autism.Molecular autism · 2019Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Importance: Despite reports of widespread but heterogeneous atypicality of functional connectivity in individuals with autism, little is known regarding the temporal dynamics of functional brain connections and how they relate to autistic traits. Objective: To investigate differences in temporal synchrony between brain regions in individuals with autism and those with typical development. Design, Setting, and Participants: This cohort study, conducted at the University of Utah, included 90 adolescent and adult male participants. A larger sample from the multisite Autism Brain Imaging Data Exchange (ABIDE) was also used as a replication sample. The study includes data acquired between December 2016 and April 2018. Aggregate data included in the replication sample were released to the public in August 2012 (ABIDE I) and June 2016 (ABIDE II). Data analysis were conducted between January 2018 and April 2018. Exposures: Male individuals diagnosed as having autism (n = 52) and typically developing male individuals (n = 38). Main Outcomes and Measures: Long duration (30 minutes/individual) of multiband, multiecho functional magnetic resonance imaging was acquired to estimate functional connectivity between brain regions. Sustained connectivity, a measure of functional connectivity duration, as well as lagged temporal dynamics related to functional connectivity, were compared between groups for 361 gray matter regions of interest and a 17-network parcellation. Lagged findings were replicated in the larger ABIDE sample (n = 1402). Sustained connectivity findings were also associated with behavioral and cognitive variables. Results: In 52 males with autism (mean [SD] age, 27.73 [8.66] years) and 38 control males with typical development (mean [SD] age, 27.09 [7.49] years), increases in both sustained and functional connectivity at several lags were found in individuals with autism compared with the control group. Group differences in functional connectivity were replicated in the larger ABIDE data set at a 6-second lag. Measures of symptom severity in individuals with autism were positively associated with sustained connectivity values. In the control group, sustained connectivity was negatively associated with cognitive processing. A replication sample (n = 1402) composed of 579 individuals with autism (80 female and 499 male; mean [SD] age, 15.08 [6.89] years) and 823 in the control group (211 female and 612 male; mean [SD] age, 15.06 [6.79] years) from the ABIDE data set was also analyzed. Conclusions and Relevance: Whereas the magnitude of functional connectivity in autism is variable across brain regions, participant samples, and development, prolonged temporal synchrony of functional connections is reproducibly observed in autism, suggesting a potential mechanism for core symptoms.
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