Evidence map›Paper›PMID 30646115›Full record

ArticleJAMA network open2018

Association of Body Mass Index With Blood Pressure Among 1.7 Million Chinese Adults.

George C Linderman, Jiapeng Lu, Yuan Lu, Xin Sun, Wei Xu, Khurram Nasir, Wade Schulz, Lixin Jiang, Harlan M Krumholz

3 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in JAMA network open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 70 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 2 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06398236 nacompletednot on this mapstarted 2023, after this paper: background citation

Multicentre, Exploratory, Prospective, Open-labelled, Non-controlled Study to Evaluate the Effect of SE5-OH Tablets on Healthy Women With Menopausal Symptoms

TypeinterventionalSponsorNutrition & Sante IberiaRan2023 to 2024Enrolled170ConditionsMenopauseArmsSE5-OH tablets
NCT06518486 nacompletednot on this mapstarted 2024, after this paper: background citation

The Effectiveness of Foot-Ankle Exercise and Walking Exercise on Foot Neuropathy, Stress, Quality of Life, Blood Sugar Markers, Blood Pressure, Ankle-Brachial Index, and BMI Among Diabetes Mellitus Patients

TypeinterventionalSponsorTaipei Medical UniversityRan2024 to 2025Enrolled375ConditionsDiabetic Foot, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Diabetes Type 2ArmsFoot-ankle exercise, Walking exercise, Usual care and health education
NCT07270328 nacompletednot on this mapstarted 2024, after this paper: background citation

A Pilot Study of Feasibility and Exploratory Study for a Definitive Randomised Controlled Trial of Foot-Ankle Versus Walking Exercises in Patients With Diabetes Mellitus: Effects on Neuropathy, Stress, and Quality of Life

TypeinterventionalSponsorTaipei Medical UniversityRan2024 to 2024Enrolled108ConditionsDiabete Mellitus, Diabete Type 2, Diabetic Peripheral Neuropathy, Diabetic FootArmsFoot-ankle exercise group, Walking exercise group, Control group
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 2 syntheses or guidelines pooled it, 166 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Study of association between serum anti-Müllerian hormone, glucose intolerance, and metabolic syndrome in women with polycystic ovarian syndrome: A comparative study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Article
  4. Article
  5. Article
  6. Lean body mass index and hypertension risk in men: a nationwide epidemiological cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. '4 Ss' for successful blood pressure control.Journal of hypertension · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

George C LindermanCenter for Outcomes Research and Evaluation, Yale-New Haven Hospital, Yale University, New Haven, Connecticut.
Jiapeng LuNational Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Yuan LuCenter for Outcomes Research and Evaluation, Yale-New Haven Hospital, Yale University, New Haven, Connecticut.
Xin SunNational Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Wei XuNational Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Khurram NasirCenter for Prevention and Wellness Research, Baptist Health Medical Group, Miami Beach, Florida.
Wade SchulzCenter for Outcomes Research and Evaluation, Yale-New Haven Hospital, Yale University, New Haven, Connecticut.
Lixin JiangNational Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Harlan M KrumholzCenter for Outcomes Research and Evaluation, Yale-New Haven Hospital, Yale University, New Haven, Connecticut.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNYale University · USBaptist Hospital of Miami · USYale New Haven Hospital · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
EFFICIENT SPECTRAL APPROACHES FOR FINDING UNDERLYING STRUCTURES IN BIG DATAR01HG008383 · NHGRI · YALE UNIVERSITY · PI KLUGER, YUVAL · 2016 to 2018
$1.2M
NCATS NIH HHS UL1 TR001863NHGRI NIH HHS R01 HG008383
6 · The paper itself

Abstract

Importance: Body mass index (BMI) is positively associated with blood pressure (BP); this association has critical implications for countries like China, where hypertension is highly prevalent and obesity is increasing. A greater understanding of the association between BMI and BP is required to determine its effect and develop strategies to mitigate it. Objective: To assess the heterogeneity in the association between BMI and BP across a wide variety of subgroups of the Chinese population. Design, Setting, and Participants: In this cross-sectional study, data were collected at 1 time point from 1.7 million adults (aged 35-80 years) from 141 primary health care sites (53 urban districts and 88 rural counties) from all 31 provinces in mainland China who were enrolled in the China PEACE (Patient-Centered Evaluative Assessment of Cardiac Events) Million Persons Project, conducted between September 15, 2014, and June 20, 2017. A comprehensive subgroup analysis was performed by defining more than 22 000 subgroups of individuals based on covariates, and within each subgroup, linearly regressing BMI to BP. Main Outcomes and Measures: Systolic BP was measured twice with the participant in a seated position, using an electronic BP monitor. Results: The study included 1 727 411 participants (1 027 711 women and 699 700 men; mean [SD] age, 55.7 [9.8] years). Among the study sample, the mean (SD) BMI was 24.7 (3.5), the mean (SD) systolic BP was 136.5 (20.4) mm Hg, and the mean (SD) diastolic BP was 81.1 (11.2) mm Hg. The increase of BP per unit BMI ranged from 0.8 to 1.7 mm Hg/(kg/m2) for 95% of the subgroups not taking antihypertensive medication. The association between BMI and BP was substantially weaker in subgroups of patients taking antihypertensive medication compared with those who were untreated. In untreated subgroups, 95% of the coefficients varied by less than 1 mm Hg/(kg/m2). Conclusions and Relevance: The association between BMI and BP is positive across tens of thousands of individuals in population subgroups, and, if causal, given its magnitude, would have significant implications for public health.

Indexed as

Blood PressureBody Mass IndexChinaFemaleHumansHypertensionMaleMiddle AgedPrevalence

Identifiers

PMID30646115
PMCPMC6324286
OpenAlexW2888337932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.