Evidence map›Paper›PMID 30645777›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2019

Lack of Myosin X Enhances Osteoclastogenesis and Increases Cell Surface Unc5b in Osteoclast-Lineage Cells.

Bo Wang, Jin-Xiu Pan, Huali Yu, Lei Xiong, Kai Zhao, Shan Xiong, Jun-Peng Guo, Sen Lin, Dong Sun, Lu Zhao and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Myosin X Interaction with KIF13B, a Crucial Pathway for Netrin-1-Induced Axonal Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Bo WangDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Jin-Xiu PanDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Huali YuDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Lei XiongDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Kai ZhaoDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Shan XiongDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Jun-Peng GuoDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Sen LinDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Dong SunDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Lu ZhaoDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Haohan GuoDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Lin MeiDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Wen-Cheng XiongDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Augusta University · USLouis Stokes Cleveland VA Medical Center · USCase Western Reserve University · USCenter for Neuroscience and Regenerative Medicine · US

Funding

APP as a common denominator for Alzheimer's disease and osteoporosisR01AG051773 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG · 2016 to 2020
$2.0M
Contributions of osteoblastic and muscular APPswe to the pathogenesis of Alzheimers diseaseR56AG060997 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG · 2018 to 2019
$800k
APPswe as a risk factor for osteoporosisI01BX000838 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI XIONG, WEN-CHENG · 2011 to 2021
–
BLRD VA I01 BX000838NIA NIH HHS R01 AG051773NIA NIH HHS R56 AG060997NIH HHS AG051773Veterans' Administration (VA) BX000838
6 · The paper itself

Abstract

Normal bone mass is maintained by balanced bone formation and resorption. Myosin X (Myo10), an unconventional "myosin tail homology 4-band 4.1, ezrin, radixin, moesin" (MyTH4-FERM) domain containing myosin, is implicated in regulating osteoclast (OC) adhesion, podosome positioning, and differentiation in vitro. However, evidence is lacking for Myo10 in vivo function. Here we show that mice with Myo10 loss of function, Myo10

Indexed as

AcebutololAnimalsHEK293 CellsHumansMiceMice, KnockoutMyosinsNetrin-1Netrin ReceptorsOsteoclastsOsteoporosisRANK LigandRAW 264.7 CellsAcebutololMyo10 protein, mouseMyosinsNetrin-1Netrin ReceptorsNtn1 protein, mouseRANK LigandTnfsf11 protein, mouseUnc5b protein, mouseBONE REMODELINGCELL SURFACEMYOSIN XOSTEOCLASTUNC5B

Identifiers

PMID30645777
PMCPMC7105956
OpenAlexW2909277891

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.