ArticlePloS one2019
Feasibility and acceptability of novel methods to estimate antiretroviral adherence: A longitudinal study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Integrated PTSD and adherence treatment for people living with HIV: a feasibility pilot trial for cognitive processing therapy- lifesteps (CPT-L) at a Ryan white clinic.AIDS research and therapy · 2025Trial
- Protocol for a Study of Home-Based Hair Sample Collection to Monitor Antiretroviral Adherence Among a Multicultural Population of Women with HIV.Research square · 2026Article
- Article
- Feasibility of remote self-collection of dried blood spots, hair, and nails among people with HIV with hazardous alcohol use.Alcohol, clinical & experimental research · 2023Article
- Virologic Nonsuppression Among Patients With HIV Newly Diagnosed With Cancer at Uganda Cancer Institute: A Cross-Sectional Study.JCO global oncology · 2023Article
- Feasibility and Acceptability of Home-Collected Samples for Human Immunodeficiency Virus Preexposure Prophylaxis and Severe Acute Respiratory Syndrome Coronavirus 2 Laboratory Tests in San Francisco Primary Care Clinics.Open forum infectious diseases · 2022Article
- Hair Zidovudine Concentrations Predict Virologic Outcomes Among People Living with HIV/AIDS in China.Patient preference and adherence · 2022Article
- Adherence to antiretroviral therapy thought package-refill among HIV+ persons at "D. Cotugno" hospital, Naples, Italy.Le infezioni in medicina · 2022Article
- Simultaneous Determination of 6 Antiretroviral Drugs in Human Hair Using an LC-ESI+-MS/MS Method: Application to Adherence Assessment.Therapeutic drug monitoring · 2021Article
- Real-Time Monitoring and Point-of-Care Testing: A Review of the Current Landscape of PrEP Adherence Monitoring.Patient preference and adherence · 2021Review
- HIV antiretroviral therapy and prevention use in US blood donors: a new blood safety concern.Blood · 2020Article
- Approaches to Objectively Measure Antiretroviral Medication Adherence and Drive Adherence Interventions.Current HIV/AIDS reports · 2020Review
- Research in the Time of Coronavirus: Continuing Ongoing Studies in the Midst of the COVID-19 Pandemic.AIDS and behavior · 2020Article
- Comparison of adherence measurement tools used in a pre-exposure prophylaxis demonstration study among female sex workers in Benin.Medicine · 2020Observational
- Moving Antiretroviral Adherence Assessments to the Modern Era: Correlations Among Three Novel Measures of Adherence.AIDS and behavior · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Due to marked reductions in morbidity and mortality, antiretroviral (ARV) adherence monitoring is of high interest. Researchers and clinicians often resort to the most feasible and cost-effective adherence methods possible, which may result in biased or inaccurate estimates and require the physical presence of a participant at a research or clinic site. The objective of our study was to evaluate the feasibility and acceptability of three objective, innovative, and remote methods to estimate ARV adherence which may be conducted with less time and financial resources in a wide range of clinic and research settings. These three methods included: (a) text-messaged photographs of pharmacy refill dates to measure refill-based adherence, (b) text-messaged photographs of ARV medications to estimate pill-count-based adherence, and (c) home-collected hair samples for the measurement of ARV concentration to determine pharmacologic-based adherence. We conducted a pilot study from March through October 2017 to examine the feasibility and acceptability of these three adherence measures and the remotely conducted study procedures in 93 adults living with HIV nationwide. From our diverse national sample of participants, 95.7% were retained until the end of the study, 89.9% sent all text messages, and 84.3% sent all hair samples. Approximately 74.2% of participants reported excellent overall experience with the study, 60.2% were very or extremely satisfied with participating in a hair collection study, and 76.3% noted extremely high likelihood of participating in a similar study including text messaging pictures of medications or refill dates. We noted high levels of feasibility and acceptability with the remote study methodology, collection of photographed and text messaged pharmacy refill dates and pill counts, and home-collected hair samples. Here we describe the feasibility and acceptability metrics, results from the exit qualitative interviews with the participants, and lessons learned. These adherence measures represent innovative approaches to expand monitoring tools for HIV treatment and prevention adherence in future research.
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