Evidence map›Paper›PMID 30645145›Full record

ArticleAmerican journal of respiratory and critical care medicine2019

Understanding Heterogeneity in Biologic Phenotypes of Acute Respiratory Distress Syndrome by Leukocyte Expression Profiles.

Lieuwe D J Bos, Brendon P Scicluna, David S Y Ong, Olaf Cremer, Tom van der Poll, Marcus J Schultz

Abstract read
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In one paragraph

Article in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Between-trial heterogeneity in ARDS research.Intensive care medicine · 2021
    Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Review
  7. Observational
  8. Cytokine storm in acute respiratory distress syndrome.Journal of intensive medicine · 2026
    Review
  9. Review
  10. Review
  11. Targeting PANoptosis: a promising therapeutic strategy for ALI/ARDS.Apoptosis : an international journal on programmed cell death · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. [Clinical sub-phenotypes of acute kidney injury in children and their association with prognosis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Article
  18. Article
  19. Article
  20. Review

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Lieuwe D J Bos1 Intensive Care, Laboratory of Experimental Intensive Care and Anesthesiology.ORCID 0000-0003-2911-4549
Brendon P Scicluna3 Center of Experimental Molecular Medicine, and.
David S Y Ong5 Department of Microbiology, Julius Center for Health Sciences and Primary Care.
Olaf Cremer7 Intensive Care, University Medical Center Utrecht, Utrecht, the Netherlands; and.
Tom van der Poll3 Center of Experimental Molecular Medicine, and.
Marcus J Schultz1 Intensive Care, Laboratory of Experimental Intensive Care and Anesthesiology.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedCohort StudiesComputational BiologyFemaleGene Expression ProfilingHumansInflammationIntensive Care UnitsLeukocytesMaleMAP Kinase Signaling SystemMiddle AgedMitochondriaOxidative PhosphorylationPhenotypeRespiratory Distress SyndromeRNA, MessengerARDSpersonalized medicinephenotypes

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.