ArticleResearch in nursing & health2019
Siyaphambili protocol: An evaluation of randomized, nurse-led adaptive HIV treatment interventions for cisgender female sex workers living with HIV in Durban, South Africa.
Article in Research in nursing & health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Sequential multiple assignment randomized trial studies should report all key components: a systematic review.Journal of clinical epidemiology · 2022Pooled it
- Longitudinal Trajectories of Engagement With HIV Treatment Support Strategies Among Female Sex Workers Living With HIV in South Africa.Journal of acquired immune deficiency syndromes (1999) · 2025Trial
- HIV- and sex work-related stigmas and quality of life of female sex workers living with HIV in South Africa: a cross-sectional study.BMC infectious diseases · 2022Trial
- General HIV-Related Knowledge and Attitudes Among Nurses and Nursing Students: A Systematic Review and Meta-Analysis with Narrative Synthesis of Clinical Practices (2011-2026).Healthcare (Basel, Switzerland) · 2026Review
- Commonality and co-occurrence of discrete strategies within implementation strategy bundles: findings from the Living Database of HIV Implementation Science systematic review, 2014-2021.Implementation science communications · 2026Review
- "It would have been easier for me to give up if I were alone": how a pilot individualized case management intervention influenced female sex workers' oral HIV pre-exposure prophylaxis use in eThekwini, South Africa.BMC public health · 2026Article
- A review of use of external data and update on reporting standards in Sequential Multiple-Assignment Randomised Trials.Clinical trials (London, England) · 2026Review
- Longitudinal patterns and predictors of opioid and stimulant use initiation and cessation among female sex workers living with HIV in South Africa.Drug and alcohol dependence · 2025Article
- Contextual Factors Influencing Implementation of HIV Treatment Support Strategies for Female Sex Workers Living With HIV in South Africa: A Qualitative Analysis Using the Consolidated Framework for Implementation Research.Journal of acquired immune deficiency syndromes (1999) · 2024Article
- Estimating the mortality risk correcting for high loss to follow-up among female sex workers with HIV in Durban, South Africa, 2018-2021.Annals of epidemiology · 2024Article
- ART coverage and viral suppression among female sex workers living with HIV in eThekwini, South Africa: Baseline findings from the Siyaphambili study.PLOS global public health · 2024Article
- PrEP discontinuation, cycling, and risk: Understanding the dynamic nature of PrEP use among female sex workers in South Africa.PloS one · 2024Article
- Prevalence of depression, syndemic factors and their impact on viral suppression among female sex workers living with HIV in eThekwini, South Africa.BMC women's health · 2023Article
- Optimizing adaptive stepped-care interventions to change adults' health behaviors: A systematic review.Journal of clinical and translational science · 2023Review
- Opportunities and considerations for the design of decentralized delivery of antiretroviral therapy for female sex workers living with HIV in South Africa.BMC health services research · 2022Article
- HIV Testing Approaches to Optimize Prevention and Treatment for Key and Priority Populations in Malawi.Open forum infectious diseases · 2022Article
- Health-related quality of life of female sex workers living with HIV in South Africa: a cross-sectional study.Journal of the International AIDS Society · 2022Article
- Occupational barriers to accessing and adhering to antiretroviral therapy for female sex workers living with HIV in South Africa.Occupational and environmental medicine · 2020Article
- Article
- HIV-Related Implementation Research for Key Populations: Designing for Individuals, Evaluating Across Populations, and Integrating Context.Journal of acquired immune deficiency syndromes (1999) · 2019Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
Abstract
In South Africa, 60% of female sex workers are estimated to be living with human immunodeficiency virus (HIV). Many of these women face structural and individual-level barriers to initiating, accessing, and adhering to antiretroviral therapy (ART). While data are limited, it is estimated that less than 40% of sex workers living with HIV achieve viral suppression, leading to suboptimal clinical outcomes and sustained risks of onward sexual and vertical HIV transmission. Siyaphambili, a NINR/NIH-funded study, focuses on studying optimal implementation strategies for meeting HIV treatment needs among cisgender female sex workers living with HIV who are not virally suppressed. Here, we present the study protocol of this sequential multiple assignment randomized trial. In total, 800 viremic female sex workers will be enrolled into an 18-month adaptive implementation study to 1) compare the effectiveness and durability of a nurse-led decentralized ART treatment program versus an individualized case management approach, in isolation or in combination to achieve viral suppression and 2) estimate incremental cost-effectiveness of interventions and combinations of interventions. The primary outcome is a combined intention-to-treat outcome of retention in ART care and viral suppression at 18 months with secondary implementation outcomes. Siyaphambili aims to inform the implementation of and scale-up of HIV treatment services for female sex workers by determining the minimal package of services needed to achieve viral suppression and by characterizing individuals in need of more intensive HIV treatment approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.