Evidence map›Paper›PMID 30644820›Full record

ArticleeLife2019

Discovering and deciphering relationships across disparate data modalities.

Joshua T Vogelstein, Eric W Bridgeford, Qing Wang, Carey E Priebe, Mauro Maggioni, Cencheng Shen

Abstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The Chi-Square Test of Distance Correlation.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joshua T VogelsteinJohns Hopkins University, Baltimore, United States.ORCID 0000-0003-2487-6237
Eric W BridgefordJohns Hopkins University, Baltimore, United States.
Qing WangJohns Hopkins University, Baltimore, United States.
Carey E PriebeJohns Hopkins University, Baltimore, United States.
Mauro MaggioniJohns Hopkins University, Baltimore, United States.
Cencheng ShenUniversity of Delaware, Delaware, United States.ORCID 0000-0003-1030-1432

Funding

Child Mind Institute Endeavor Scientist Program
6 · The paper itself

Abstract

Understanding the relationships between different properties of data, such as whether a genome or connectome has information about disease status, is increasingly important. While existing approaches can test whether two properties are related, they may require unfeasibly large sample sizes and often are not interpretable. Our approach, 'Multiscale Graph Correlation' (MGC), is a dependence test that juxtaposes disparate data science techniques, including k-nearest neighbors, kernel methods, and multiscale analysis. Other methods may require double or triple the number of samples to achieve the same statistical power as MGC in a benchmark suite including high-dimensional and nonlinear relationships, with dimensionality ranging from 1 to 1000. Moreover, MGC uniquely characterizes the latent geometry underlying the relationship, while maintaining computational efficiency. In real data, including brain imaging and cancer genetics, MGC detects the presence of a dependency and provides guidance for the next experiments to conduct.

Indexed as

AlgorithmsData AnalysisBiomarkers, TumorBrainComputer SimulationHumansNeoplasmsSample SizeBiomarkers, Tumorcomputational biologydata sciencehumanmachine learningneurosciencestatisticssystems biology

Identifiers

PMID30644820
PMCPMC6386524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.