ArticleMolecular psychiatry2021
Genetic influence on cognitive development between childhood and adulthood.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Early predictors of neurodevelopment after perinatal arterial ischemic stroke: a systematic review and meta-analysis.Pediatric research · 2023Pooled it
- Associations between polygenic risk for obesity, body mass index and cognitive performance: Age as moderating factor.Brain, behavior, & immunity - health · 2026Article
- Common and rare genetic variant associations with cognitive performance across development in British birth cohorts.Nature human behaviour · 2026Article
- Gene × sex interactions on cognition in the Philadelphia neurodevelopmental cohort.Biology of sex differences · 2026Article
- Family income and polygenic scores are independently but not interactively associated with cognitive performance among youth genetically similar to European reference populations.Development and psychopathology · 2025Article
- Genetic foundations of interindividual neurophysiological variability.Science advances · 2025Article
- Article
- Genetic Foundations of Inter-individual Neurophysiological Variability.bioRxiv : the preprint server for biology · 2025Article
- Gestational Age and Cognitive Development in Childhood.JAMA network open · 2025Article
- Genetic contribution to intrinsic functional connectivity underlying general intelligence: evidence from adult twin study.Brain communications · 2025Article
- Cognitive performance from childhood to old age and intergenerational correlations in the multigenerational Young Finns Study.Journal of neurology · 2024Article
- TheToxics · 2024Article
- Heritability of cerebellar subregion volumes in adolescent and young adult twins.Human brain mapping · 2024Article
- Dissociation of Reliability, Heritability, and Predictivity in Coarse- and Fine-Scale Functional Connectomes during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Validation of the cognitive section of the Penn computerized adaptive test for neurocognitive and clinical psychopathology assessment (CAT-CCNB).Brain and cognition · 2024Article
- The Impact of Genetics on Cognition: Insights into Cognitive Disorders and Single Nucleotide Polymorphisms.Journal of personalized medicine · 2024Article
- The dynamic influence of nutrition on prolonged cognitive healthspan across the life course: A perspective review.Neuroscience applied · 2024Review
- KIBRA single nucleotide polymorphism is associated with hippocampal subfield volumes and cognition across development.Brain structure & function · 2024Article
- Association of Time in Bed, Social Jetlag, and Sleep Disturbances With Cognitive Performance in Children With ADHD.Journal of attention disorders · 2024Article
- Computerized Cognitive Test Batteries for Children and Adolescents-A Scoping Review of Tools For Lab- and Web-Based Settings From 2000 to 2021.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Successful cognitive development between childhood and adulthood has important consequences for future mental and physical wellbeing, as well as occupational and financial success. Therefore, delineating the genetic influences underlying changes in cognitive abilities during this developmental period will provide important insights into the biological mechanisms that govern both typical and atypical maturation. Using data from the Philadelphia Neurodevelopmental Cohort (PNC), a large population-based sample of individuals aged 8 to 21 years old (n = 6634), we used an empirical relatedness matrix to establish the heritability of general and specific cognitive functions and determine if genetic factors influence cognitive maturation (i.e., Gene × Age interactions) between childhood and early adulthood. We found that neurocognitive measures across childhood and early adulthood were significantly heritable. Moreover, genetic variance on general cognitive ability, or g, increased significantly between childhood and early adulthood. Finally, we did not find evidence for decay in genetic correlation on neurocognition throughout childhood and adulthood, suggesting that the same genetic factors underlie cognition at different ages throughout this developmental period. Establishing significant Gene × Age interactions in neurocognitive functions across childhood and early adulthood is a necessary first step in identifying genes that influence cognitive development, rather than genes that influence cognition per se. Moreover, since aberrant cognitive development confers risk for several psychiatric disorders, further examination of these Gene × Age interactions may provide important insights into their etiology.
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