ArticleScientific reports2019
Characterization of a male specific region containing a candidate sex determining gene in Atlantic cod.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- ONYX: an alignment-free biological sex inference from high-throughput sequencing data.Frontiers in bioinformatics · 2026Article
- Screening a new European hake (Merluccius merluccius) chromosome-level genome assembly suggests an XX/XY sex-determining system driven by the SRY-box transcription factor 3 (sox3).G3 (Bethesda, Md.) · 2025Article
- Prematuration differences in male and female Atlantic cod: Investigating sex ratio, length and ecotype disparities in juveniles.Journal of fish biology · 2025Article
- The Cause-Effect Model of Master Sex Determination Gene Acquisition and the Evolution of Sex Chromosomes.International journal of molecular sciences · 2025Review
- Understanding Genetic Regulation of Sex Differentiation in Hermaphroditic Fish.Animals : an open access journal from MDPI · 2025Review
- Genome assemblies forFrontiers in genetics · 2024Article
- Master-Key Regulators of Sex Determination in Fish and Other Vertebrates-A Review.International journal of molecular sciences · 2023Review
- Low-coverage whole-genome sequencing reveals molecular markers for spawning season and sex identification in Gulf of Maine Atlantic cod (Ecology and evolution · 2021Article
- RADSex: A computational workflow to study sex determination using restriction site-associated DNA sequencing data.Molecular ecology resources · 2021Article
- A novel c.1759T>G variant in follicle-stimulating hormone-receptor gene is concordant with male determination in the flathead grey mullet (Mugil cephalus).G3 (Bethesda, Md.) · 2021Article
- Identification of Sex-Specific Markers Through 2b-RAD Sequencing in the Sea Urchin (Frontiers in genetics · 2021Article
- Deciphering the Origin and Evolution of the XInternational journal of molecular sciences · 2019Article
- Genome-wide RAD sequencing to identify a sex-specific marker in Chinese giant salamander Andrias davidianus.BMC genomics · 2019Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetic mechanisms determining sex in teleost fishes are highly variable and the master sex determining gene has only been identified in few species. Here we characterize a male-specific region of 9 kb on linkage group 11 in Atlantic cod (Gadus morhua) harboring a single gene named zkY for zinc knuckle on the Y chromosome. Diagnostic PCR test of phenotypically sexed males and females confirm the sex-specific nature of the Y-sequence. We identified twelve highly similar autosomal gene copies of zkY, of which eight code for proteins containing the zinc knuckle motif. 3D modeling suggests that the amino acid changes observed in six copies might influence the putative RNA-binding specificity. Cod zkY and the autosomal proteins zk1 and zk2 possess an identical zinc knuckle structure, but only the Y-specific gene zkY was expressed at high levels in the developing larvae before the onset of sex differentiation. Collectively these data suggest zkY as a candidate master masculinization gene in Atlantic cod. PCR amplification of Y-sequences in Arctic cod (Arctogadus glacialis) and Greenland cod (Gadus macrocephalus ogac) suggests that the male-specific region emerged in codfishes more than 7.5 million years ago.
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