Evidence map›Paper›PMID 30644359›Full record

ArticleeLife2019

Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity.

Patpicha Arunsan, Wannaporn Ittiprasert, Michael J Smout, Christina J Cochran, Victoria H Mann, Sujittra Chaiyadet, Shannon E Karinshak, Banchob Sripa, Neil David Young, Javier Sotillo and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Chromosome-Contiguous Reference Genome forInternational journal of molecular sciences · 2025
    Article
  5. Review
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  7. Applications of CRISPR in Parasitology.Current pharmaceutical biotechnology · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Trematode Genomics and Proteomics.Advances in experimental medicine and biology · 2024
    Article
  12. Review
  13. Article
  14. Modelling morbidity for neglected tropical diseases: the long and winding road from cumulative exposure to long-term pathology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  15. Review
  16. Article
  17. Review
  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Patpicha Arunsan *Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Wannaporn Ittiprasert *Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, United States.ORCID 0000-0001-9411-8883
Michael J Smout *Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia.ORCID 0000-0001-6937-0112
Christina J CochranDepartment of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, United States.
Victoria H MannDepartment of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, United States.
Sujittra ChaiyadetDepartment of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Shannon E KarinshakDepartment of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, United States.ORCID 0000-0002-2079-0973
Banchob SripaDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Neil David YoungFaculty of Veterinary and Agricultural Sciences, The University of Melbourne, Victoria, Australia.ORCID 0000-0001-8756-229X
Javier SotilloCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia.ORCID 0000-0002-1443-7233
Alex Loukas *Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia.
Paul J Brindley *Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, United States.ORCID 0000-0003-1765-0002
Thewarach Laha *Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
George Washington University · USKhon Kaen University · THAustralian Institute of Tropical Health and Medicine · AUThe University of Melbourne · AU

Funding

Targeting parasite-host communication to combat liver fluke-induced bile duct cancerR01CA164719 · NCI · GEORGE WASHINGTON UNIVERSITY · PI Paul J Brindley, THEWARACH LAHA · 2012 to 2026
$5.0M
NCI NIH HHS R01 CA164719NCI NIH HHS R01CA164719Wellcome Trust
6 · The paper itself

Abstract

Infection with the food-borne liver fluke

Indexed as

Gene Knockout TechniquesAnimalsBile Ducts, IntrahepaticCarcinogenesisCell LineCell ProliferationChronic DiseaseCricetinaeCRISPR-Cas SystemsFibrosisGene EditingGene Expression RegulationGenomeGranulinsHumansHyperplasiaGranulinscarcinogenicgene-editinginfectious diseasemicrobiologyOpisthorchis viverrini

Identifiers

PMID30644359
PMCPMC6355195
OpenAlexW2910099164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.