Evidence map›Paper›PMID 30644326›Full record

ArticleJournal of psychopharmacology (Oxford, England)2019

Dopamine manipulations drive changes in information sampling in healthy volunteers.

Raquel Vicario-Feliciano, Rebekah L Wigton, Thomas P White, Sukhi S Shergill, Bruno B Averbeck

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychopharmacology (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Raquel Vicario-Feliciano1 Laboratory of Neuropsychology, National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-9788-4820
Rebekah L Wigton2 Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Thomas P White2 Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Sukhi S Shergill2 Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Bruno B Averbeck1 Laboratory of Neuropsychology, National Institutes of Health (NIH), Bethesda, MD, USA.
National Institutes of Health · USUniversity of Birmingham · GB

Funding

Frontal Striatal Systems and Dopamine in Normal and Pathological BehaviorZIAMH002928 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI AVERBECK, BRUNO · 2010 to 2025
$29.0M
European Research Council 311686Intramural NIH HHS ZIA MH002928Medical Research Council G0901868
6 · The paper itself

Abstract

backgroundInformation sampling is the cognitive process of accumulating information before committing to a decision. Patients across numerous disorders show decreased information sampling relative to controls.

aimsHere, we used the Beads and the Best Choice Tasks to study the role of dopamine signaling in information sampling.

methodsParticipants were given placebo, amisulpride, or ropinirole in each session, in a double-blind cross-over design.

resultsWe found that ropinirole (agonist) increased the number of beads drawn in the Beads Task specifically when participants faced a loss, and decreased the rank of the chosen option in the Best Choice Task.

conclusionsThese effects are likely driven by a combination of effects at presynaptic D

Indexed as

AdultChoice BehaviorCorpus StriatumCross-Over StudiesDecision MakingDopamineDopamine AntagonistsDopamine D2 Receptor AntagonistsDouble-Blind MethodFemaleHealthy VolunteersHumansIndolesMaleReceptors, Dopamine D1Receptors, Dopamine D2DopamineDopamine AntagonistsDopamine D2 Receptor AntagonistsIndolesReceptors, Dopamine D1Receptors, Dopamine D2ropiniroleDopamineinformation samplingneural circuitspsychopharmacology

Identifiers

PMID30644326
PMCPMC6996051
OpenAlexW2909518288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.