Evidence map›Paper›PMID 30644272›Full record

ReviewZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2019

[Research progress on the role of thrombospondin in synapse formation].

Chaoyang Gong, Gao Xiang, Kaixin Liu, Haihong Zhang

Open access · greenAbstract readReview
In one paragraph

Review in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chaoyang GongDepartment of Orthopedics, Gansu Key Laboratory of Osteoarthropathy Research, Lanzhou University Second Hospital, Lanzhou Gansu, 730000, P.R.China.
Gao XiangDepartment of Orthopedics, Gansu Key Laboratory of Osteoarthropathy Research, Lanzhou University Second Hospital, Lanzhou Gansu, 730000, P.R.China.
Kaixin LiuDepartment of Orthopedics, Gansu Key Laboratory of Osteoarthropathy Research, Lanzhou University Second Hospital, Lanzhou Gansu, 730000, P.R.China.
Haihong ZhangDepartment of Orthopedics, Gansu Key Laboratory of Osteoarthropathy Research, Lanzhou University Second Hospital, Lanzhou Gansu, 730000, P.R.China.zhanghaihong1968@sina.com.
Lanzhou University Second Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To review the recent progress in the role of thrombospondins (TSPs) in synapse formation in the central nervous system (CNS). Methods: A wide range of domestic and foreign literature on the role of TSPs in the synapse formation of the CNS was reviewed. The role of TSPs in structural features, molecules, and related diseases was reviewed. Results: As an oligosaccharide protein, TSPs play important roles in angiogenesis, inflammation, osteogenesis, cell proliferation, and apoptosis. In the nervous system, they bind to voltage-dependent calcium channels, neuronectin, and other extracellular matrix proteins and cell surface receptors, and participate in and regulate multiple processes such as synapse formation, maturation, and function in the CNS. Conclusion: TSPs as an oligomeric extracellular matrix protein play an important role in the formation of synapses and the repair of synapses after CNS injury.

Indexed as

Calcium ChannelsNeurogenesisSynapsesThrombospondinsCell ProliferationCalcium ChannelsThrombospondinsneuroliginsynapseThrombospondinsvoltage-dependent calcium channel

Identifiers

PMID30644272
PMCPMC8337251
OpenAlexW2997735230

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.