ReviewCellular microbiology2019
Role of distinct type-IV-secretion systems and secreted effector sets in host adaptation by pathogenic Bartonella species.
Review in Cellular microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 49 citations in OpenAlex.
- Description ofInternational journal of systematic and evolutionary microbiology · 2026Article
- Genomic characterization of eight novel Bartonella species from bats and ectoparasites reveals phylogenetic diversity and host adaptation.PLoS neglected tropical diseases · 2025Article
- Comparison of transcriptomic profiles between intracellular and extracellular Bartonella henselae.Communications biology · 2025Article
- Sneaky tactics: Ingenious immune evasion mechanisms ofVirulence · 2024Review
- From host individual traits to community structure and composition: Bartonella infection insights.Parasites & vectors · 2024Article
- Translocation of YopJ family effector proteins through the VirB/VirD4 T4SS ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Analysis of twelve genomes of the bacteriumPeerJ · 2024Article
- Comparison of Biological Activities of BafA Family Autotransporters withinInfection and immunity · 2023Article
- Genomic Characterization of Three NovelMicroorganisms · 2023Article
- Limitations of Serological Diagnosis of Typical Cat Scratch Disease and Recommendations for the Diagnostic Procedure.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023Review
- Advancements in understanding the molecular and immune mechanisms ofFrontiers in microbiology · 2023Review
- Identification of theProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Adaptive immune defense prevents Bartonella persistence upon trans-placental transmission.PLoS pathogens · 2022Article
- Emerging rodent-associated Bartonella: a threat for human health?Parasites & vectors · 2022Review
- Article
- Long-Read Sequencing Reveals Genetic Adaptation ofFrontiers in microbiology · 2022Article
- Honey bee genetics shape the strain-level structure of gut microbiota in social transmission.Microbiome · 2021Article
- Undercover Agents of Infection: The Stealth Strategies of T4SS-Equipped Bacterial Pathogens.Toxins · 2021Review
- Evaluating Transmission Paths for Three DifferentMicroorganisms · 2021Article
- Bats are key hosts in the radiation of mammal-associated Bartonella bacteria.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The α-proteobacterial genus Bartonella comprises a large number of facultative intracellular pathogens that share a common lifestyle hallmarked by hemotrophic infection and arthropod transmission. Speciation in the four deep-branching lineages (L1-L4) occurred by host adaptation facilitating the establishment of long lasting bacteraemia in specific mammalian reservoir host(s). Two distinct type-IV-secretion systems (T4SSs) acquired horizontally by different Bartonella lineages mediate essential host interactions during infection and represent key innovations for host adaptation. The Trw-T4SS confined to the species-rich L4 mediates host-specific erythrocyte infection and likely has functionally replaced flagella as ancestral virulence factors implicated in erythrocyte colonisation by bartonellae of the other lineages. The VirB/VirD4-T4SS translocates Bartonella effector proteins (Bep) into various host cell types to modulate diverse cellular and innate immune functions involved in systemic spreading of bacteria following intradermal inoculation. Independent acquisition of the virB/virD4/bep locus by L1, L3, and L4 was likely driven by arthropod vectors associated with intradermal inoculation of bacteria rather than facilitating direct access to blood. Subsequently, adaptation to colonise specific niches in the new host has shaped the evolution of complex species-specific Bep repertoires. This diversification of the virulence factor repertoire of Bartonella spp. represents a remarkable example for parallel evolution of host adaptation.
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