Evidence map›Paper›PMID 30644044›Full record

ReviewClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2019

Time for radioimmunotherapy: an overview to bring improvements in clinical practice.

O Leaman Alcibar, D Candini, F López-Campos, M Albert Antequera, V Morillo Macías, A J Conde, A Rodríguez Pérez, A Hervás Morón, J Contreras Martínez, C Ferrer Albiach and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 2 countries.

O Leaman AlcibarRadiation Oncology Department, Central University Hospital of Defence Gómez Ulla, Madrid, Spain. olwenleaman@gmail.com.ORCID http://orcid.org/0000-0002-0638-2164
D CandiniRadiation Oncology Department, Ramón y Cajal University Hospital, Madrid, Spain.
F López-CamposRadiation Oncology Department, Ramón y Cajal University Hospital, Madrid, Spain.
M Albert AntequeraRadiation Oncology Department, La Ribera University Hospital, Valencia, Spain.
V Morillo MacíasRadiation Oncology Department, General Hospital in Castellón de la Plana, Castellón, Spain.
A J CondeRadiation Oncology Department, The University and Polytechnic La Fe Hospital, Valencia, Spain.
A Rodríguez PérezRadiation Oncology Department, Internacional Ruber Hospital, Madrid, Spain.
A Hervás MorónRadiation Oncology Department, Ramón y Cajal University Hospital, Madrid, Spain.
J Contreras MartínezRadiation Oncology Department, Málaga Hospital, Málaga, Spain.
C Ferrer AlbiachRadiation Oncology Department, General Hospital in Castellón de la Plana, Castellón, Spain.
S Navarro AguilarRadiation Oncology Department, Oncology and Radiotherapy Institut, Ricardo Palma Clinic, Lima, Peru.
M E Rodríguez-RuizRadiation Oncology Department, University of Navarra Clinic and CIMA, Navarra, Spain.
Instituto Cajal · ESHospital General Universitari de Castelló · ESHospital Central de la Defensa Gómez Ulla · ESHospital de La Ribera · ESHospital Regional Universitario de Málaga · ESHospital Ruber Internacional · ESHospital Universitari i Politècnic La Fe · ESUniversidad de Navarra · ESUniversidad Ricardo Palma · PE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Harnessing the patient's own immune system against an established cancer has proven to be a successful strategy. Within the last years, several antibodies blocking critical "checkpoints" that control the activation of T cells, the immune cells able to kill cancer cells, have been approved for the use in patients with different tumours. Unfortunately, these cases remain a minority. Over the last years, radiotherapy has been reported as a means to turn a patient's own tumour into an in situ vaccine and generate anti-tumour T cells in patients who lack sufficient anti-tumour immunity. Indeed, review data show that the strategy of blocking multiple selected immune inhibitory targets in combination with radiotherapy has the potential to unleash powerful anti-tumour responses and improve the outcome of metastatic solid tumours. Here, we review the principal tumours where research in this field has led to new knowledge and where radioimmunotherapy becomes a reality.

Indexed as

HumansNeoplasmsPrognosisRadioimmunotherapyAbscopal effectImmunogenic neoplasmsImmunotherapy combinationsRadioimmunotherapyRadiotherapy

Identifiers

PMID30644044
OpenAlexW2908559017

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.