ArticleEuropean radiology2019
MR extracellular volume mapping and non-contrast T1ρ mapping allow early detection of myocardial fibrosis in diabetic monkeys.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 39 citations in OpenAlex.
- Dark-Blood AdiabaticBioengineering (Basel, Switzerland) · 2026Article
- Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation.The Journal of physiology · 2026Review
- The first oral relaxin receptor RXFP1 agonist for heart failure treatment: Translational studies from non-human primates to humans.Molecular therapy. Advances · 2026Article
- Endogenous assessment of late gadolinium enhancement grey area in patients with chronic myocardial infarction using T1rho mapping.Quantitative imaging in medicine and surgery · 2025Article
- Multiparametric quantitative magnetic resonance imaging of skeletal muscle in CKD.American journal of physiology. Renal physiology · 2025Article
- Supaglutide alleviates hepatic steatosis in monkeys with spontaneous MASH.Diabetology & metabolic syndrome · 2024Article
- Early detection of myocardial involvement by non-contrast T1ρ mapping of cardiac magnetic resonance in type 2 diabetes mellitus.Frontiers in endocrinology · 2024Article
- Cardiovascular magnetic resonance imaging for sequential assessment of cardiac fibrosis in mice: technical advancements and reverse translation.American journal of physiology. Heart and circulatory physiology · 2024Review
- Robust cardiacMagnetic resonance in medicine · 2023Article
- Replacement substance P reduces cardiac fibrosis in monkeys with type 2 diabetes.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023Article
- Hemoglobin A1c in type 2 diabetes mellitus patients with preserved ejection fraction is an independent predictor of left ventricular myocardial deformation and tissue abnormalities.BMC cardiovascular disorders · 2023Article
- Imaging characterization of myocardial function, fibrosis, and perfusion in a nonhuman primate model with heart failure-like features.Frontiers in cardiovascular medicine · 2023Article
- Dynamic changes in cardiac morphology, function, and diffuse myocardial fibrosis duration of diabetes in type 1 and type 2 diabetic mice models using 7.0 T CMR and echocardiography.Frontiers in endocrinology · 2023Article
- Quantification correction for free-breathing myocardial TJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022Article
- The Road Toward Reproducibility of Parametric Mapping of the Heart: A Technical Review.Frontiers in cardiovascular medicine · 2022Review
- Endogenous assessment of myocardial injury with single-shot model-based non-rigid motion-corrected T1 rho mapping.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021Article
- Fibrosis of the diabetic heart: Clinical significance, molecular mechanisms, and therapeutic opportunities.Advanced drug delivery reviews · 2021Review
- Is MRI relaxometry parameter TQuantitative imaging in medicine and surgery · 2020Article
- Evaluating the correlation of the impairment between skeletal muscle and heart using MRI in a spontaneous type 2 diabetes mellitus rhesus monkey model.Acta diabetologica · 2020Article
- Metabolic and Molecular Imaging of the Diabetic Cardiomyopathy.Circulation research · 2020Review
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo detect diffuse myocardial fibrosis in different severity levels of left ventricular diastolic dysfunction (DD) in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys.
methodsEighteen spontaneous T2DM and nine healthy monkeys were studied. Echocardiography was performed for diastolic function classification. Cardiac magnetic resonance (CMR) imaging was performed to obtain extracellular volume fraction (ECV) maps and T1ρ maps at two different spin-locking frequencies. ECV values, T1ρ values, and myocardial fibrosis index (mFI) values which are based on the dispersion of T1ρ, were calculated. Global peak diastolic longitudinal strain rates (GSrL) were also obtained.
resultsEchocardiography results showed mild DD in nine T2DM monkeys and moderate DD in the other nine. The global ECV values were significantly different among healthy animals as compared with animals with mild DD or moderate DD, and the ECV values of animals with moderate DD were significantly higher as compared with those of mild DD. The mFI values increased progressively from healthy animals to those with mild DD and then to those with moderate DD. Diastolic function indicators (e.g., early diastolic mitral annulus velocity, GSrL) correlated well with ECV and mFI.
conclusionsMonkeys with T2DM exhibit increased ECV, T1ρ, and mFI values, which may be indicative of the expansion of extracellular volume and the deposition of excessive collagen. T1ρ mapping may have the potential to be used for diffuse myocardial fibrosis assessment. KEY POINTS: • Monkeys with T2DM exhibit increased ECV, T1ρ, and mFI values, which may be indicative of the expansion of extracellular volume and the deposition of excessive collagen. • The relationship between diastolic dysfunction and diffuse myocardial fibrosis may be demonstrated by imaging markers. • Non-contrast T1ρ mapping may have the potential to be used for diffuse myocardial assessment.
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