Evidence map›Paper›PMID 30643812›Full record

Trial reportBioMed research international2018

Effects of Plasma Albumin on the Pharmacokinetics of Esomeprazole in ICU Patients.

Hsin Tian, Yanyan Xu, Jiayan Wang, Weiqiang Tian, Jian Sun, Tao Zhang, Qingyun Zhou, Chuxiao Shao

Open access · hybridAbstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hsin TianDepartment of Intensive Care Medicine, Lishui Hospital of Zhejiang University, Lishui, Zhejiang 323000, China.
Yanyan XuDepartment of Pharmacy, Lishui Hospital of Zhejiang University, Lishui, Zhejiang 323000, China.
Jiayan WangDepartment of Intensive Care Medicine, Lishui Hospital of Zhejiang University, Lishui, Zhejiang 323000, China.
Weiqiang TianDepartment of Pharmacy, Lishui Hospital of Zhejiang University, Lishui, Zhejiang 323000, China.
Jian SunDepartment of Intensive Care Medicine, Lishui Hospital of Zhejiang University, Lishui, Zhejiang 323000, China.
Tao ZhangDepartment of Intensive Care Medicine, Lishui Hospital of Zhejiang University, Lishui, Zhejiang 323000, China.
Qingyun ZhouDepartment of General Surgery, Lishui Hospital of Zhejiang University, Lishui, Zhejiang 323000, China.
Chuxiao ShaoDepartment of General Surgery, Lishui Hospital of Zhejiang University, Lishui, Zhejiang 323000, China.ORCID 0000-0002-7154-1723
Lishui University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the effects of plasma albumin on pharmacokinetics of esomeprazole in ICU patients.

methodsThis study was performed in 32 consecutive intensive care unit (ICU) patients. They were divided into two groups according to the plasma albumin levels. Nineteen patients with low plasma albumin levels (<30 g/L; male/female, 12/7) were assigned to low plasma albumin group (LPAG). Thirteen patients with plasma albumin levels >30 g/L (male/female, 9/4) were assigned to high plasma albumin group (HPAG). All patients were received intravenous (IV) of 40 mg esomeprazole in 5 min. Blood samples were collected via basilic vein at different time points and concentrations of esomeprazole were determined by UPLC-MS/MS.

resultsMRT

conclusionsSome pharmacokinetic parameters of esomeprazole may be changed in ICU patients with low plasma albumin.

Indexed as

Intensive Care UnitsAdolescentAdultAgedAged, 80 and overEsomeprazoleFemaleHumansMaleMiddle AgedSerum Albumin, HumanEsomeprazoleSerum Albumin, Human

Identifiers

PMID30643812
PMCPMC6311297
OpenAlexW2904570537

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.