ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2019
In Situ Investigation of Interrelationships Between Morphology and Biomechanics of Endothelial and Glial Cells and their Nuclei.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Material-Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Reconstructing 3D transcriptional organization from spatial transcriptomics reveals consistent oncogenic translocations and developmental dynamics.Briefings in bioinformatics · 2026Article
- Mechanical properties of the brain: Focus on the essential role of Piezo1-mediated mechanotransduction in the CNS.Brain and behavior · 2023Review
- A role for nuclear stretching and NPCs changes in the cytoplasmic-nuclear trafficking of YAP: An experimental and numerical modelling approach.Materials today. Bio · 2022Article
- Review
- Multiscale Mechanobiology in Brain Physiology and Diseases.Frontiers in cell and developmental biology · 2022Review
- Data acquisition and imaging using wavelet transform: a new path for high speed transient force microscopy.Nanoscale advances · 2021Article
- Nanomechanical properties of enucleated cells: contribution of the nucleus to the passive cell mechanics.Journal of nanobiotechnology · 2020Article
- Opportunities and Challenges for Biosensors and Nanoscale Analytical Tools for Pandemics: COVID-19.ACS nano · 2020Review
- Correlating nuclear morphology and external force with combined atomic force microscopy and light sheet imaging separates roles of chromatin and lamin A/C in nuclear mechanics.Molecular biology of the cell · 2020Article
- Review
- Nuclear Envelope Permeability Barrier as a Fast-Response Intracellular Mechanostat.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- A Biophysical Model for Curvature-Guided Cell Migration.Biophysical journal · 2019Article
- In Situ Investigation of Interrelationships Between Morphology and Biomechanics of Endothelial and Glial Cells and their Nuclei.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphology and biomechanics of cells and nuclei are interlinked with one another and play key roles in fundamental physiological processes. While powerful approaches are available for performing separate morphological and biomechanical investigations on cells and nuclei, simultaneous investigations in situ are challenging. Here, an appropriate approach is presented based on the simultaneous combination of atomic force microscopy and confocal microscopy in situ. Two cell types with entirely different morphologies, physiological roles, and biomechanical environments are investigated: vascular endothelial cells (ECs) with dense cytoskeletal actin, and nervous system glial cells (Schwann cells (SCs)) with dense vimentin network. Results reveal that ECs and their nuclei show high pliability and tend to undergo deformation only at compression sites. SCs, in contrast, show greater ability to resist mechanical deformation. Likewise, SC nuclei are harder to deform than EC nuclei, despite that SC nuclei have significantly lower amounts of lamins A/C, which reportedly scale with nuclear stiffness. The morphology-biomechanics interrelationships in SCs, ECs, and their nuclei may be a key factor in ensuring their physiological functions. In adult SCs, mechanosensitivity is presumably traded for mechanical strength to protect the neurons they encase, whereas ECs maintain mechanosensitivity to ensure specific local physiological response to mechanical stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.