Evidence map›Paper›PMID 30643671›Full record

ArticleClinical psychological science : a journal of the Association for Psychological Science2018

Ventrolateral prefrontal cortex activation during social exclusion mediates the relation between intolerance of uncertainty and trait aggression.

Stephanie M Gorka, K Luan Phan, Bobak Hosseini, Eunice Y Chen, Michael S McCloskey

Abstract read
In one paragraph

Article in Clinical psychological science : a journal of the Association for Psychological Science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Article
  4. Article
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  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stephanie M GorkaUniversity of Illinois-Chicago; Department of Psychiatry, 1747 West Roosevelt Road Chicago, IL 60608.
K Luan PhanUniversity of Illinois-Chicago; Department of Psychiatry, 1747 West Roosevelt Road Chicago, IL 60608.
Bobak HosseiniUniversity of Illinois-Chicago; Department of Psychiatry, 1747 West Roosevelt Road Chicago, IL 60608.
Eunice Y ChenTemple University; Department of Psychology, 1701 North 13 Street Philadelphia, PA 19122.
Michael S McCloskeyTemple University; Department of Psychology, 1701 North 13 Street Philadelphia, PA 19122.

Funding

Cognitive Behavioral Aggression Treatment: Effects on Brain and BehaviorR01MH086525 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI MCCLOSKEY, MICHAEL S · 2010 to 2014
$2.6M
Brain-Behavior Reactivity to Threat and Alcohol Abuse Risk in Young AdultsK23AA025111 · NIAAA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GORKA, STEPHANIE · 2017 to 2020
$764k
NIAAA NIH HHS K23 AA025111NIMH NIH HHS R01 MH086525
6 · The paper itself

Abstract

Intolerance of uncertainty (IU) is an important individual difference factor that may contribute to trait-like aggression. Deficient engagement of the ventrolateral PFC (vlPFC) during social situations may also be a mechanism that links these two constructs. The aim of the current study was to test a proposed mediation model whereby IU is associated with trait aggression through neural activation of the vlPFC during a social exclusion task. Fifty-three adults with a range of impulsive-aggressive traits completed validated assessments of IU and trait aggression, and the 'Cyberball' social exclusion task during functional magnetic resonance imaging (fMRI). Results supported the mediation model such that greater levels of IU were associated with greater trait aggression through hypoactivation of the vlPFC during social exclusion. This study is the first to provide evidence suggesting that individuals higher in IU have difficulties engaging regulatory neural processes, which in-turn may increase the propensity for aggression.

Indexed as

aggressionintolerance of uncertaintysocial exclusionventrolateral prefrontal cortex

Identifiers

PMID30643671
PMCPMC6329470

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.