ReviewTremor and other hyperkinetic movements (New York, N.Y.)2018
Essential Tremor and Parkinson's Disease: Exploring the Relationship.
Review in Tremor and other hyperkinetic movements (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 4 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- GWAS meta-analysis reveals key risk loci in essential tremor pathogenesis.Communications biology · 2024Pooled it
- Speech, voice, and language outcomes following deep brain stimulation: A systematic review.PloS one · 2024Pooled it
- The global prevalence of essential tremor, with emphasis on age and sex: A meta-analysis.Journal of global health · 2021Pooled it
- Imaging the Pathophysiology of Essential Tremor-A Systematic Review.Frontiers in neurology · 2021Pooled it
- Differentiating tremor-dominant parkinson's disease from essential tremor using neuromelanin- sensitive imaging and T1w/T2w ratio.NPJ Parkinson's disease · 2026Article
- Insights from a cross-sectional population-based study of 10,929 Australians living with Parkinson's disease: risk factors, comorbidities, and sex differences.The Lancet regional health. Western Pacific · 2026Article
- Tremor management strategies in Parkinson's disease: optimizing patient care.Neurodegenerative disease management · 2026Review
- Prevalence of Probable REM Sleep Behavior Disorder in Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Article
- Neuroprotective effects of telmisartan in a harmaline-induced model of essential tremor: modulation of the renin-angiotensin system and inflammatory pathways.Frontiers in pharmacology · 2026Article
- Diagnostic value of multi-regional multi-parameter transcranial sonography in differentiating Parkinson's disease from essential tremor.Frontiers in neurology · 2026Article
- Resting and action tremor in Parkinson's disease: pathophysiological insights from long-term STN-DBS.NPJ Parkinson's disease · 2025Article
- Burden of tremor in Parkinson's disease: A survey study.Journal of Parkinson's disease · 2025Article
- Risk of Parkinson's disease in older people with tremor: A population-based prospective study.Journal of Parkinson's disease · 2025Article
- The Association Between Essential Tremor and Parkinson's Disease: A Systematic Review of Clinical and Epidemiological Studies.Journal of clinical medicine · 2025Review
- Striatal Dopaminergic Function and Motor Slowing in Essential Tremor Plus.Movement disorders clinical practice · 2025Article
- Applying Wearable Sensors and Machine Learning to the Diagnostic Challenge of Distinguishing Parkinson's Disease from Other Forms of Parkinsonism.Biomedicines · 2025Article
- Nonmotor Symptoms Differ Between Essential Tremor and Tremor-Dominant Parkinson's Disease.Brain and behavior · 2025Article
- Identification of a metabolic brain network characterizing essential tremor.Scientific reports · 2025Article
- Multimodal Magnetic Resonance Findings in Parkinson's Disease With "Antecedent Essential Tremor": A Case Series of a Large Kindred.Neuropsychiatric disease and treatment · 2025Article
- Association Between Common Variants in theInternational journal of molecular sciences · 2024Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: There is longstanding controversy surrounding the possible link between essential tremor (ET) and Parkinson's disease (PD). Inconsistent and unreliable diagnostic criteria may in part account for some of the difficulties in defining the relationship between these two common movement disorders. Methods: References for this systematic review were identified using PubMed with the search terms "essential tremor" AND "Parkinson's disease" with articles published in English between 1960 and September 2018 included. Results: In this review we provide evidence that some patients diagnosed with ET have an increased risk of developing PD years or decades after onset of action tremor. There are several still unresolved questions about the link between the two disorders including lack of verifiable diagnostic criteria for the two disorders and marked overlap in phenomenology. Here we review clinical, epidemiologic, imaging, pathologic, and genetic studies that address the ET-PD relationship. Several lines of evidence support the association between ET and PD, including overlapping motor and non-motor features, relatively high prevalence of rapid eye movement sleep behavior disorder (26-43%) in ET patients, increased prevalence of PD in patients with longstanding antecedent ET, increased prevalence of ET in family members of patients with PD, and the presence of Lewy bodies in the brains of some ET patients (15-24%). Discussion: There is a substantial body of evidence supporting the association between ET and PD within at least a subset of patients, although the nature and possible pathogenic mechanisms of the relationship are not well understood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.